Search results
Results from the WOW.Com Content Network
Decreased activity of mitochondrial PDH with age has been shown in the heart as well as in certain regions of the brain (the striatum and brainstem). [6] Pyruvate dehydrogenase (PDH) deficiency is a congenital degenerative metabolic disease resulting from a mutation of the pyruvate dehydrogenase complex (PDC) located on the X chromosome.
Pymol-generated image of E1 subunit of pyruvate dehydrogenase complex in E. Coli. The E1 subunit, called the pyruvate dehydrogenase subunit, is either a homodimer (comprising two “α” chains, e.g. in Escherichia coli) or a heterotetramer of two different chains (two “α” and two “β” chains).
The PDHB gene is responsible for the coding of the E1 beta subunit of the pyruvate dehydrogenase complex. The DLAT gene is responsible for the coding of the E2 subunit, and the PDP1 is responsible for producing the PDH phosphatase catalytic subunit that catalyzes PDH dephosphorylation. This dephosphorylation activates the complex.
The mitochondrial PDH and OGDH are part of biochemical pathways that result in the generation of adenosine triphosphate (ATP), which is the main energy transfer molecule for the cell. [3] In the nervous system, PDH is also involved in the synthesis of myelin and the neurotransmitter acetylcholine. [14]
The parasympathetic nervous system in the motor nuclei of cranial nerves III, VII, IX, (control over the pupil and salivary glands) and X (vagus –many functions including immunity) and sacral spinal segments (gastrointestinal and urogenital systems). [12] Another control occurs through top down control by the medial areas of the prefrontal ...
The axons of the parvocellular neurosecretory neurons of the PVN project to the median eminence, a neurohemal organ at the base of the brain, where their neurosecretory nerve terminals release their hormones at the primary capillary plexus of the hypophyseal portal system. The median eminence contains fiber terminals from many hypothalamic ...
PDH may refer to: Angiotensin-converting enzyme, an enzyme; Plesiochronous digital hierarchy, in telecommunications networks; Pound–Drever–Hall technique for ...
The brain consumes large amounts of energy but does not have a reservoir of stored energy substrates. Since higher processes in the brain occur almost constantly, cerebral blood flow is essential for the maintenance of neurons , astrocytes , and other cells of the brain.