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  2. Huntington's disease - Wikipedia

    en.wikipedia.org/wiki/Huntington's_disease

    The area of the brain most damaged in early Huntington's disease is the dorsal striatum made up of the caudate nucleus and the putamen. Initially, damage to the brain is regionally specific with the dorsal striatum in the subcortical basal ganglia being primarily affected, followed later by cortical involvement in all areas.

  3. Huntingtin - Wikipedia

    en.wikipedia.org/wiki/Huntingtin

    Huntingtin (Htt) is the protein coded for in humans by the HTT gene, also known as the IT15 ("interesting transcript 15") gene. [5] Mutated HTT is the cause of Huntington's disease (HD), and has been investigated for this role and also for its involvement in long-term memory storage.

  4. List of neurological conditions and disorders - Wikipedia

    en.wikipedia.org/wiki/List_of_neurological...

    This is a list of major and frequently observed neurological disorders (e.g., Alzheimer's disease), symptoms (e.g., back pain), signs (e.g., aphasia) and syndromes (e.g., Aicardi syndrome). There is disagreement over the definitions and criteria used to delineate various disorders and whether some of these conditions should be classified as ...

  5. Dementia - Wikipedia

    en.wikipedia.org/wiki/Dementia

    Huntington's disease is a neurodegenerative disease caused by mutations in a single gene HTT, that encodes for huntingtin protein. Symptoms include cognitive impairment and this usually declines further into dementia. [83] The first main symptoms of Huntington's disease often include: difficulty concentrating; memory lapses

  6. Nancy Wexler - Wikipedia

    en.wikipedia.org/wiki/Nancy_Wexler

    Nancy Wexler attended many workshops including her own. She was most impressed by the workshop of George Hunting which was a film showing Huntington disease patients as a part of a community near Lake Maracaibo in comparison to most U.S patients confined to nursing homes. [3] Years later, Nancy became involved in the Venezuela research. [3]

  7. Memory disorder - Wikipedia

    en.wikipedia.org/wiki/Memory_disorder

    Huntington's disease (HD) is an inherited progressive disorder of the brain that leads to uncontrolled movements, emotional instability, and loss of intellectual faculties. [19] Because of the inheritability of Huntington's each child born to a parent with Huntington's has a 50% chance of inheriting the disease, leading to a prevalence of ...

  8. The Lion's Mouth Opens - Wikipedia

    en.wikipedia.org/wiki/The_Lion's_Mouth_Opens

    The film begins at a dinner party. Filmmaker and actress Marianna Palka, 33 years old, is joined by friends in anticipation of the genetic testing results she will receive the next day, revealing whether or not she has inherited the presently untreatable neurodegenerative illness, Huntington's disease, from her father, who has the illness.

  9. Spinocerebellar ataxia type 1 - Wikipedia

    en.wikipedia.org/wiki/Spinocerebellar_ataxia_type_1

    [41] [42] Spinocerebellar ataxia type 1 was one of the first late onset diseases for which presymptomatic testing was demonstrated effective and predictive; prior to the development of testing for SCA1, Huntington's disease was the only similar disease for which presymptomatic testing was available. [44]

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