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The house mouse (Mus musculus) has a gestation period of 19 to 21 days. Key events in mouse brain development occur both before and after birth, beginning with peak neurogenesis of the cranial motor nuclei 9 days after conception, up to eye opening which occurs after birth and about 30 days after conception.
The Allen Mouse Brain Atlas is a comprehensive genome-wide map of the adult mouse brain that reveals where each gene is expressed. [3] The mouse brain atlas was the original project of the Allen Brain Atlas and was finished in 2006. The purpose of the atlas is to aid in the development of neuroscience research.
On November 14, 2008, the Allen Institute for Brain Science announced the launch of the Allen Developing Mouse Brain Atlas, providing a highly detailed map of gene activity in the mouse brain at several time points across development, [12] including four embryonic ages, three postnatal, and aging time points. [13]
Stages of neuronal development in the fetal cerebral cortex Model of mammalian neurogenesis [4]. During embryonic development, the mammalian central nervous system (CNS; brain and spinal cord) is derived from the neural tube, which contains NSCs that will later generate neurons. [3]
Allen Brain Atlas [2] Mouse Brain Library [3] High resolution mouse brain atlas; BrainMaps. High-Resolution Brain Maps and Brain Atlases of Mus musculus; Despite superficial differences, especially in size and weight, the mouse brain and its function can serve as a powerful animal model for study of human brain diseases or mental disorders (see ...
Other bone morphogenetic proteins are also known to impact corticogenesis in the mouse. Bmp2, 4, 5, and 6 are expressed during the process and can compensate for one another. For example, if Bmp-4 was absent from corticogenesis, very little would change in the cortex phenotype, due to the other Bmps helping accomplish the tasks of Bmp-4.
The development of sensory maps requires learning, long term potentiation, experience-dependent plasticity, and innate characteristics. [1] There is significant evidence for experience-dependent development and maintenance of sensory maps, and there is growing evidence on the molecular basis, synaptic basis and computational basis of experience ...
Fate mapping shows which tissues come from which part of the embryo at a certain stage in development, whereas cell lineage shows the relationships between cells at each division. [12] A cell lineage can be used to generate a fate map, and in cases like C. elegans, successive fate mapping can be used to develop a cell lineage. [13]