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Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer occurring in about three people per million members of the population. [1] It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. [2]
Merkel cell carcinoma (also known as Merkel cell skin cancer) is a rare type of cancer where malignant cells form in the skin, according to the National Cancer Institute (NCI).
Merkel cells, also known as Merkel–Ranvier cells or tactile epithelial cells, are oval-shaped mechanoreceptors essential for light touch sensation and found in the skin of vertebrates. They are abundant in highly sensitive skin like that of the fingertips in humans , and make synaptic contacts with somatosensory afferent nerve fibers .
Of nonmelanoma skin cancers, about 80% are basal-cell cancers and 20% squamous-cell skin cancers. [14] Basal-cell and squamous-cell skin cancers rarely result in death. [6] In the United States, they were the cause of less than 0.1% of all cancer deaths. [1] Globally in 2012, melanoma occurred in 232,000 people and resulted in 55,000 deaths. [6]
Cancer Research UK has recently warned that skin cancer cases are set to rise by half by 2040. Skip to main content. 24/7 Help. For premium support please call: 800-290-4726 ...
As with all skin cancers, sun exposure is a risk factor, as is a compromised immune system and previous history of skin cancer. 5 things to know about Merkel cell carcinoma, the rare cancer that ...
Merkel cell carcinoma is a highly aggressive type of skin cancer that was first described by Cyril Toker in 1972 as "trabecular tumor of the skin". [20] Based on its origin, the cancer cell type is called a neuroectodermal tumor.
Singer-songwriter Jimmy Buffett, who died September 1, had Merkel cell carcinoma, a skin cancer that’s diagnosed in fewer than 3,000 people in the US every year.