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Izzie's presence continues to influence Alex throughout later seasons, particularly in his relationship with Jo Wilson (Camilla Luddington). In the Season 12, "I Choose You", Jo discovers an invoice from the fertility clinic that stored the embryos created when Izzie had cancer, sparking questions about whether Alex might have children with ...
Meanwhile, the hospital is filled with tension as the doctors and residents try to impress their superiors, hoping to survive the impending merger with Mercy West. Izzie Stevens (Katherine Heigl) returns to work full-time, despite still recovering from her cancer treatment, wearing an auburn wig to conceal her hair loss.
Meanwhile, Izzie Stevens (Katherine Heigl) misses her scheduled Interleukin 2 cancer treatment, leaving Alex Karev (Justin Chambers) distraught. Derek spends 10 hours in the OR analyzing the tumor, supported by Mark Sloan , Miranda Bailey (Chandra Wilson), and Callie Torres (Sara Ramirez). Despite Webber's orders to stop the surgery, Isaac ...
Unable to cope with the emotional strain alone, Cristina tells the other residents about Izzie’s condition, leading to Izzie being admitted to Seattle Grace Hospital as a patient. Meanwhile, Mark Sloan prepares for a complex face transplant surgery, selecting Izzie and Lexie Grey (Chyler Leigh) to assist him. The decision to involve Izzie ...
Izzie is preparing for her brain surgery and, in her hospital room, she reminds her friends that they have patients to care for and urges them to focus on saving lives. Miranda Bailey ( Chandra Wilson ) gathers the residents, reminding them that Izzie needs friends, not doctors, at this moment.
Izzie struggles to make the decision and asks her friends for guidance, but they only promise unconditional support. To help Izzie make an informed choice, they conduct a neurological test, which goes poorly as Izzie fails to remember basic images or speak properly. This unsettles Meredith, who urges Izzie not to go through with the surgery.
Residential drug treatment co-opted the language of Alcoholics Anonymous, using the Big Book not as a spiritual guide but as a mandatory text — contradicting AA’s voluntary essence. AA’s meetings, with their folding chairs and donated coffee, were intended as a judgment-free space for addicts to talk about their problems.
Following the cliffhanger of season 5, Izzie is shown to have survived, but gets a bad wake up call: George has died. While the staff mourns George's death, Meredith and the other residents are unsure how to continue with their lives and each must learn to deal with it in their own way.