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A corepressor downregulates (or represses) the expression of genes by binding to and activating a repressor transcription factor. The repressor in turn binds to a gene's operator sequence (segment of DNA to which a transcription factor binds to regulate gene expression), thereby blocking transcription of that gene.
Corepressor proteins also bind to the surface of the ligand binding domain of nuclear receptors, but through a LXXXIXXX(I/L) motif of amino acids (where L = leucine, I = isoleucine and X = any amino acid). [7] In addition, compressors bind preferentially to the apo (ligand free) form of the nuclear receptor (or possibly antagonist bound receptor).
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.
54880 71458 Ensembl ENSG00000183337 ENSMUSG00000040363 UniProt Q6W2J9 Q8CGN4 RefSeq (mRNA) NM_001123383 NM_001123384 NM_001123385 NM_001130139 NM_017745 NM_020926 NM_001168321 NM_029510 NM_175044 NM_175045 NM_175046 RefSeq (protein) NP_001116855 NP_001116856 NP_001116857 NP_060215 NP_001161793 NP_083786 NP_778209 NP_778210 NP_778211 Location (UCSC) Chr X: 40.05 – 40.18 Mb Chr X: 11.9 – 12. ...
20185 Ensembl ENSG00000141027 ENSMUSG00000018501 UniProt O75376 Q60974 RefSeq (mRNA) NM_001190438 NM_001190440 NM_006311 NM_001252313 NM_011308 NM_177229 RefSeq (protein) NP_001177367 NP_001177369 NP_006302 n/a Location (UCSC) Chr 17: 16.03 – 16.22 Mb Chr 11: 62.21 – 62.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The nuclear receptor co-repressor 1 also known as thyroid ...
The ability of nuclear receptors to alternate between activation and repression in response to specific molecular cues, is now known to be attributable in large part to a diverse group of cellular factors, collectively termed coregulators and including coactivators and corepressors.
254251 209707 Ensembl ENSG00000178177 ENSMUSG00000015882 UniProt Q8N3X6 Q3U285 RefSeq (mRNA) NM_001166139 NM_153686 NM_001163073 NM_172153 NM_178142 NM_001359871 NM_001359872 NM_001359873 NM_001359874 RefSeq (protein) NP_001159611 NP_710153 NP_001352587 NP_001352588 NP_001352589 NP_001352590 NP_001352591 NP_001352592 NP_001352594 NP_001156545 NP_742165 NP_835278 NP_001346800 NP_001346801 NP ...
66556 Ensembl ENSG00000175550 ENSMUSG00000024914 UniProt Q14919 Q9D6N5 RefSeq (mRNA) NM_006442 NM_001291080 NM_024176 RefSeq (protein) NP_006433 NP_001278009 NP_077138 Location (UCSC) Chr 11: 65.92 – 65.92 Mb Chr 19: 5.47 – 5.48 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene. Transcriptional ...