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Biotin, synthesized in plants, is essential to plant growth and development. [22] Bacteria also synthesize biotin, [23] and it is thought that bacteria resident in the large intestine may synthesize biotin that is absorbed and utilized by the host organism. [18] Biosynthesis starts from two precursors, alanine and pimeloyl-CoA. These form 7 ...
β-Hydroxy β-methylbutyric acid [note 1] (HMB), otherwise known as its conjugate base, β-hydroxy β-methylbutyrate, is a naturally produced substance in humans that is used as a dietary supplement and as an ingredient in certain medical foods that are intended to promote wound healing and provide nutritional support for people with muscle wasting due to cancer or HIV/AIDS.
As an intermediate in the metabolism of biotin, biocytin occurs naturally in blood serum and urine. The enzyme biotinidase cleaves biocytin and makes biotin available to be reused by other enzymes. Because biocytin is the natural substrate of the enzyme biotinidase, biocytin can be used to measure the biotinidase activity and therefore diagnose ...
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