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Non-specific effects of vaccines (also called "heterologous effects" or "off-target effects") are effects which go beyond the specific protective effects against the targeted diseases. Non-specific effects from live vaccines can be strongly beneficial by increasing protection against non-targeted infections. [ 1 ]
Complement proteins are proteins that play a role in the non-specific immune responses alongside these non-specific immune cells to make up the first line of immune defense. [4] The non-specific immune response is an immediate antigen-independent response, however it is not antigen-specific. Non-specific immunity results in no immunologic memory.
Innate immune defenses are non-specific, meaning these systems respond to pathogens in a generic way. [19] This system does not confer long-lasting immunity against a pathogen. The innate immune system is the dominant system of host defense in most organisms, [2] and the only one in plants. [20]
Bacteria (and perhaps other prokaryotic organisms), utilize a unique defense mechanism, called the restriction modification system to protect themselves from pathogens, such as bacteriophages. In this system, bacteria produce enzymes, called restriction endonucleases, that attack and destroy specific regions of the viral DNA of invading ...
The purpose is to reduce the risk of death and suffering, [1] that is, the disease burden, even when eradication of the disease is not possible. Vaccination is the chief type of such immunization, greatly reducing the burden of vaccine-preventable diseases. Immunity against infections that can cause serious illness is beneficial.
The following outline is provided as an overview of and topical guide to concepts related to infectious diseases in humans.. Infection – transmission, entry/invasion after evading/overcoming defense, establishment, and replication of disease-causing microscopic organisms (pathogens) inside a host organism, and the reaction of host tissues to them and to the toxins they produce.
The U.N. agency is negotiating new rules to shore up the world's defences against future pathogens following the COVID-19 pandemic that has killed nearly 7 million people worldwide.
The innate immune system is made of non-specific defensive mechanisms against foreign cells inside the host including skin as a physical barrier to entry, activation of the complement cascade to identify foreign bacteria and activate necessary cell responses, and white blood cells that remove foreign substances.