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Haemochromatosis is protean in its manifestations, i.e., often presenting with signs or symptoms suggestive of other diagnoses that affect specific organ systems.Many of the signs and symptoms below are uncommon, and most patients with the hereditary form of haemochromatosis do not show any overt signs of disease nor do they have premature morbidity, if they are diagnosed early, but, more ...
Hemorrhoids (or haemorrhoids), also known as piles, are vascular structures in the anal canal. [ 7 ] [ 8 ] In their normal state, they are cushions that help with stool control. [ 2 ] They become a disease when swollen or inflamed ; the unqualified term hemorrhoid is often used to refer to the disease. [ 8 ]
The hallmark feature of oxytosis/ferroptosis is the iron-dependent accumulation of oxidatively damaged phospholipids (i.e., lipid peroxides).The implication of Fenton chemistry via iron is crucial for the generation of reactive oxygen species and this feature can be exploited by sequestering iron in lysosomes. [32]
Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]
Antioxidative stress is an overabundance of bioavailable antioxidant compounds that interfere with the immune system's ability to neutralize pathogenic threats. The fundamental opposite is oxidative stress, which can lead to such disease states as coronary heart disease or cancer.
For example, a 2024 narrative review found that drinking red wine might help prevent dementia. This is, again, thanks to the antioxidants in red wine, which may help prevent oxidative stress and ...
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