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Actinic keratosis (AK), sometimes called solar keratosis or senile keratosis, [1] [2] is a pre-cancerous [3] area of thick, scaly, or crusty skin. [ 4 ] [ 5 ] Actinic keratosis is a disorder ( -osis ) of epidermal keratinocytes that is induced by ultraviolet (UV) light exposure ( actin- ).
Keratosis (from kerat-+ -osis) [1] is a growth of keratin on the skin or on mucous membranes stemming from keratinocytes, the prominent cell type in the epidermis. More specifically, it can refer to: actinic keratosis (also known as solar keratosis), a premalignant condition; chronic scar keratosis; hydrocarbon keratosis
Actinic keratosis, pre-cancerous area of thick, scaly, or crusty skin (Below) with cutaneous horn tissue (above) Cutaneous horns , also known by the Latin name cornu cutaneum , are unusual keratinous skin tumors with the appearance of horns, or sometimes of wood or coral.
SCC of the skin begins as a small nodule and as it enlarges the center becomes necrotic and sloughs and the nodule turns into an ulcer, and generally are developed from an actinic keratosis. Once keratinocytes begin to grow uncontrollably, they have the potential to become cancerous and produce cutaneous squamous-cell carcinoma. [22]
Hydrocarbon keratosis (pitch keratosis, tar keratosis, tar wart) Hyperkeratosis lenticularis perstans (Flegel's disease) Hyperkeratosis of the nipple and areola; Hyperkeratotic actinic keratosis; Ichthyosis hystrix (ichthyosis hystrix gravior type Lambert, porcupine man, systematized verrucous nevus) Ichthyosis hystrix of Curth–Macklin
Actinic cheilitis is cheilitis (lip inflammation) caused by long term sunlight exposure. Essentially it is a burn , [ 2 ] and a variant of actinic keratosis which occurs on the lip. [ 5 ] It is a premalignant condition , [ 6 ] as it can develop into squamous cell carcinoma (a type of mouth cancer ).
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Early actinic keratosis with parakeratosis, with black arrows indicating one of multiple retained nuclei in the stratum corneum. Parakeratosis is a mode of keratinization characterized by the retention of nuclei in the stratum corneum. [1] In mucous membranes, parakeratosis is normal. [2]
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