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H 1-receptor antagonists are competitive inhibitor of histamine receptor H 1 and are used to treat allergies. This group is often referred simply as antihistamines . Wikimedia Commons has media related to H1 receptor antagonists .
H 1 antagonists, also called H 1 blockers, are a class of medications that block the action of histamine at the H 1 receptor, helping to relieve allergic reactions.Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines; other agents may have antihistaminergic action but are not true antihistamines.
Risperidone (Risperdal) – dopamine D 2 and D 3 receptor antagonist, serotonin 5-HT 1B, 5-HT 2A, 5-HT 2C, and 5-HT 7 receptor antagonist or inverse agonist, α 1 - and α 2-adrenergic receptor antagonist, histamine H 1 receptor inverse agonist, and atypical antipsychotic [98] [97]
Histamine receptors expressed in smooth muscles, vascular endothelial cells, the heart, and the central nervous system. [7] This prevents a range of cellular signaling cascades that lead to vasodilation and increased membrane permeability from happening, thus preventing allergic symptoms.
Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is an antihistamine medication. [8] It is used in the treatment of itchiness, anxiety, insomnia, and nausea (including that due to motion sickness). [8]
[medical citation needed] Loratadine is a long-acting antihistamine (H 1 histamine antagonist) that is less sedating than older substances of its type. [medical citation needed] In 2022, it was the 289th most commonly prescribed medication in the United States, with more than 500,000 prescriptions. [2] [3]
Clemastine, also known as meclastin, is a first-generation H1 histamine antagonist (antihistamine) with anticholinergic properties (drying) and sedative side effects. [1] Like all first-generation antihistamines, it is sedating. [2] [3] Patented in 1960, it came into medical use in 1967. [4]
Alcaftadine, sold under the brand name Lastacaft, is an antihistamine used to help prevent itching of the eyes. [1] It is an H1 histamine receptor antagonist. [1] It is given as an drops in the eye. [1] It was approved for medical use in the United States in July 2010. [3] It is available as a generic medication and as an over-the-counter ...