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  2. Programmed cell death protein 1 - Wikipedia

    en.wikipedia.org/wiki/Programmed_cell_death...

    Programmed cell death protein 1 (PD-1), (CD279 cluster of differentiation 279). PD-1 is a protein encoded in humans by the PDCD1 gene. [5] [6] PD-1 is a cell surface receptor on T cells and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity.

  3. Response evaluation criteria in solid tumors - Wikipedia

    en.wikipedia.org/wiki/Response_Evaluation...

    Progressive disease (PD): At least a 20% increase in the sum of the LD of target lesions, taking as reference the smallest sum LD recorded since the treatment started or the appearance of one or more new lesions; Evaluation of non-target lesions. Complete response (CR): Disappearance of all non-target lesions and normalization of tumor marker level

  4. PD-1 and PD-L1 inhibitors - Wikipedia

    en.wikipedia.org/wiki/PD-1_and_PD-L1_inhibitors

    PD-1 and PD-L1 inhibitors act to inhibit the association of the programmed death-ligand 1 with its receptor, programmed cell death protein 1 (PD-1). The interaction of these cell surface proteins is involved in the suppression of the immune system and occurs following infection to limit the killing of bystander host cells and prevent autoimmune ...

  5. List of medical abbreviations: P - Wikipedia

    en.wikipedia.org/wiki/List_of_medical...

    PD: Parkinson's disease paroxysmal dyskinesia peritoneal dialysis physical diagnosis personality disorder program director PDA: patent ductus arteriosus posterior descending artery: PDD: premenstrual dysphoric disorder PDE: phosphodiesterase: PDGF: platelet-derived growth factor: PDR: Physicians' Desk Reference. Proliferative Diabetic ...

  6. Checkpoint inhibitor - Wikipedia

    en.wikipedia.org/wiki/Checkpoint_inhibitor

    PD-L1 on the cell surface binds to PD-1 on an immune cell surface, which inhibits immune cell activity. Among PD-L1 functions is a key regulatory role on T cell activities. [3] [4] It appears that (cancer-mediated) upregulation of PD-L1 on the cell surface may inhibit T cells that might otherwise attack. Antibodies that bind to either PD-1 or ...

  7. List of abbreviations used in medical prescriptions - Wikipedia

    en.wikipedia.org/wiki/List_of_abbreviations_used...

    This is a list of abbreviations used in medical prescriptions, including hospital orders (the patient-directed part of which is referred to as sig codes).This list does not include abbreviations for pharmaceuticals or drug name suffixes such as CD, CR, ER, XT (See Time release technology § List of abbreviations for those).

  8. List of abbreviations for diseases and disorders - Wikipedia

    en.wikipedia.org/wiki/List_of_abbreviations_for...

    PD Parkinson's disease: PDD Pervasive developmental disorder: PDD-NOS Pervasive developmental disorder, not otherwise specified: PDD/NOS Pervasive developmental disorder, not otherwise specified: PDS Pokkuri Death Syndrome PE Pulmonary embolism: PKAN Panthothenate kinase-associated neurodegeneration: PLMD Periodic limb movement disorder: PLS

  9. PD-L1 - Wikipedia

    en.wikipedia.org/wiki/PD-L1

    The affinity between PD-L1 and PD-1, as defined by the dissociation constant K d, is 770 nM. PD-L1 also has an appreciable affinity for the costimulatory molecule CD80 (B7-1), but not CD86 (B7-2). [11] CD80's affinity for PD-L1, 1.4 μM, is intermediate between its affinity for CD28 and CTLA-4 (4.0 μM and 400 nM