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In oncology, polycythemia vera (PV) is an uncommon myeloproliferative neoplasm in which the bone marrow makes too many red blood cells. [1] The majority of cases [2] are caused by mutations in the JAK2 gene, most commonly resulting in a single amino acid change in its protein product from valine to phenylalanine at position 617.
[6] [7] [8] [1] [9] In mice, high levels of Lac-Phe in the blood cause a decrease of food intake [6] and in humans, its production has been shown to correlate with adipose tissue loss during an endurance exercise intervention. [10] In mammals it is created from -lactate and L-phenylalanine by the cytosol nonspecific dipeptidase (CNDP2) protein. [1]
Phenylalanine ball and stick model spinning. Phenylalanine (symbol Phe or F) [3] is an essential α-amino acid with the formula C 9 H 11 NO 2.It can be viewed as a benzyl group substituted for the methyl group of alanine, or a phenyl group in place of a terminal hydrogen of alanine.
The basic cause of sporadic (non-familial) cancers is DNA damage and genomic instability. [1] [2] A minority of cancers are due to inherited genetic mutations. [3] Most cancers are related to environmental, lifestyle, or behavioral exposures. [4] Cancer is generally not contagious in humans, though it can be caused by oncoviruses and cancer ...
Studies in other animals or in humans did not show the same effect and there is no evidence showing FD&C Red No. 3 causes cancer in humans. That said, Vanessa Rissetto, R.D., ...
Carcinogens are defined as 'a substance or agent that can cause cells to become cancerous by altering their genetic structure so that they multiply continuously and become malignant'. [1] The World Health Organization breaks down the three types of carcinogens that can cause cancer in humans. The first type of carcinogen is the physical type ...
The "radiofrequency electromagnetic fields" associated with using mobile phones are "possibly cancer-causing". Like aspartame, this means there is either limited evidence they can cause cancer in ...
The IARC said in a release Thursday that it was classifying aspartame as possibly carcinogenic, meaning there is some evidence that it may cause cancer in humans, but that the evidence is far from ...