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  2. Pharmacokinetics - Wikipedia

    en.wikipedia.org/wiki/Pharmacokinetics

    Pharmacokinetics is based on mathematical modeling that places great emphasis on the relationship between drug plasma concentration and the time elapsed since the drug's administration. Pharmacokinetics is the study of how an organism affects the drug, whereas pharmacodynamics (PD) is the study of

  3. Antibacterial soap - Wikipedia

    en.wikipedia.org/wiki/Antibacterial_soap

    Claims that antibacterial soap is effective stem from the long-standing knowledge that triclosan can inhibit the growth of various bacteria, as well as some fungi. [2] However, more recent reviews have suggested that antibacterial soaps are no better than regular soaps at preventing illness or reducing bacteria on the hands of users. [2] [7]

  4. Physiologically based pharmacokinetic modelling - Wikipedia

    en.wikipedia.org/wiki/Physiologically_based...

    The drug has an elimination half-life of 4 hours, and an apparent volume of distribution of 10 liters. Pharmacokinetic model of drugs entering a tumor. (A) Schematic illustration of a tumor vessel illustrating loss of smooth muscle cells, local degradation of the extracellular matrix, and increased permeability of the endothelium.

  5. Lipinski's rule of five - Wikipedia

    en.wikipedia.org/wiki/Lipinski's_Rule_of_Five

    Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.

  6. PK/PD model - Wikipedia

    en.wikipedia.org/wiki/PK/PD_model

    Central to PK/PD models is the concentration-effect or exposure-response relationship. [4] A variety of PK/PD modeling approaches exist to describe exposure-response relationships . PK/PD relationships can be described by simple equations such as linear model, Emax model or sigmoid Emax model . [ 5 ]

  7. Quantitative systems pharmacology - Wikipedia

    en.wikipedia.org/wiki/Quantitative_Systems...

    [1] [2] QSP can be viewed as a sub-discipline of pharmacometrics that focuses on modeling the mechanisms of drug pharmacokinetics (PK), pharmacodynamics (PD), and disease processes using a systems pharmacology point of view.

  8. Malcolm Rowland - Wikipedia

    en.wikipedia.org/wiki/Malcolm_Rowland

    Rowland has published over 270 research articles in international peer-reviewed journals, and over 60 book chapters and conference reports. He co-authored with Thomas Tozer two standard textbooks: Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications, now in its 5th edition, and Essentials of Pharmacokinetics and Pharmacodynamics.

  9. Pharmacometrics - Wikipedia

    en.wikipedia.org/wiki/Pharmacometrics

    The term "pharmacometrics" first appeared in literature in the preface of the 1964 book "Evaluation of Drug Activities: Pharmacometrics" [3]: The sub-title of the book is, as far as we are aware, a neologism, coined by one of us (A.L.B.), and the word is defined by the main title of the book, which could have been even more explicitly, if more verbosely, expressed as "The Identification and ...