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Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain. [2]
[30] [31] In August 2014, the FDA approved apixaban for the additional indication of the treatment of recurring deep vein thrombosis and pulmonary embolism. [30] [32] During its development the drug was known as BMS-562247-01. [33] By late 2019, sales of the product by BMS accounted for thirty percent of their quarterly revenue. [34]
Synthesis of apixaban, as published by Pinto, et al. in 2007. [30] The notable key step is a (3+2)cycloaddition of the p-methoxyphenylchlorohydrazon derivate and the p-iodophenyl-morpholin-dihydropyridin derivate in the first reaction.
This is a list of abbreviations used in medical prescriptions, including hospital orders (the patient-directed part of which is referred to as sig codes).This list does not include abbreviations for pharmaceuticals or drug name suffixes such as CD, CR, ER, XT (See Time release technology § List of abbreviations for those).
The Nursing Interventions Classification (NIC) is a care classification system which describes the activities that nurses perform as a part of the planning phase of the nursing process associated with the creation of a nursing care plan.
Concomitant use of these and edoxaban may require 30 mg doses of edoxaban (instead of 60 mg). The efficacy of edoxaban may decrease when it is used with strong P-gp inducers such as phenytoin, carbamazepine, phenobarbital or St. John's Wort. If these medications are used with edoxaban, caution is advised. [12]
The common side effects of this combination are those of its individual drugs. For instance, the use of inhaled corticosteroids is associated with oral candidiasis, commonly known as yeast infection or thrush.
The choice of using 50% was arbitrary, but proved to be useful in further works by R. A. Fish in 1963, [147] where he established a luminosity concentration law that relates the brightnesses of elliptical galaxies and their respective R e, and by José Luis Sérsic in 1968 [148] that defined a mass-radius relation in galaxies.