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Kawasaki disease (also known as mucocutaneous lymph node syndrome) is a syndrome of unknown cause that results in a fever and mainly affects children under 5 years of age. [6] It is a form of vasculitis, in which medium-sized blood vessels become inflamed throughout the body. [1]
Kawasaki disease is most commonly seen in infants and children under five years old and is more likely to affect boys. The disease is self-limited which means that the inflammation will resolve after 6 to 8 weeks but if we left it untreated, there is a 20-25% risk of the heart complications we went over. Alright so let’s look at the symptoms ...
Tomisaku Kawasaki (川崎 富作, Kawasaki Tomisaku, February 1, 1925 – June 5, 2020) was a Japanese pediatrician who first described the condition now known as Kawasaki disease in the 1960s. [ 1 ] [ 2 ] Alongside rheumatic heart disease , Kawasaki disease is considered to be the leading cause of acquired heart disease in children worldwide.
Human infectious diseases may be characterized by their case fatality rate (CFR), the proportion of people diagnosed with a disease who die from it (cf. mortality rate).It should not be confused with the infection fatality rate (IFR), the estimated proportion of people infected by a disease-causing agent, including asymptomatic and undiagnosed infections, who die from the disease.
Kawasaki disease is a type of vasculitis where the endothelial cells in the coronary arteries become damaged, potentially leading to complications like myocardial infarction and aneurysms. This video covers the known pathophysiology, important signs and symptoms, diagnostic criteria, and treatment.
Coronary artery disease (atherosclerosis) Vasculitic and connective tissue diseases (Kawasaki and Marfan) Intracoronary manipulation leading to local wall stress (stent placement, angioplasty, brachytherapy) Post-infectious as a consequence of direct wall infiltration or immune complex deposition [8]
Though this disease is a type of coronary vasculitis, coronary vasculitis isn't exclusively kawasaki disease. If it is meant to be representative of kawasaki disease then the 2% quoted is most likely a SMR, or standard mortality ratio, that quantifies an increase in mortality relative to the general population.
For example, various Global Burden of Disease Studies investigate such factors and quantify recent developments – one such systematic analysis analyzed the (non)progress on cancer and its causes during the 2010–19-decade, indicating that 2019, ~44% of all cancer deaths – or ~4.5 M deaths or ~105 million lost disability-adjusted life years ...