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A polygene is a member of a group of non-epistatic genes that interact additively to influence a phenotypic trait, thus contributing to multiple-gene inheritance (polygenic inheritance, multigenic inheritance, quantitative inheritance [1]), a type of non-Mendelian inheritance, as opposed to single-gene inheritance, which is the core notion of Mendelian inheritance.
Beside the environment factor, genetic variants can be detected for personality traits. These traits are polygenic. Significant genetic variants are present for most of the behavioral traits. There is a consistency in detection of genetic variants and genomic association for traits derived from pedigree. [3]
At present the best-understood examples of polygenic adaptation are in humans, and particularly for height, a trait that can be interpreted using data from genome-wide association studies. In a 2012 paper, Joel Hirschhorn and colleagues showed that there was a consistent tendency for the "tall" alleles at genome-wide significant loci to be at ...
This approach to genetic association studies is largely atheoretical, and typically not guided by a particular biological hypothesis regarding the phenotype. [33] Genetic association findings for behavioural traits and psychiatric disorders have been found to be highly polygenic (involving many small genetic effects).
[1] [2] Intelligence in the normal range is a polygenic trait, meaning that it is influenced by more than one gene, [3] [4] and in the case of intelligence at least 500 genes. [5] Further, explaining the similarity in IQ of closely related persons requires careful study because environmental factors may be correlated with genetic factors.
A quantitative trait locus (QTL) is a region of DNA which is associated with a particular phenotypic trait, which varies in degree and which can be attributed to polygenic effects, i.e., the product of two or more genes, and their environment. [2]
The basic principle behind psychiatric genetics is that genetic polymorphisms (as indicated by linkage to e.g. a single nucleotide polymorphism) are part of the causation of psychiatric disorders. [1] Psychiatric genetics is a somewhat new name for the old question, "Are behavioral and psychological conditions and deviations inherited?".
The infinitesimal model, also known as the polygenic model, is a widely used statistical model in quantitative genetics and in genome-wide association studies.Originally developed in 1918 by Ronald Fisher, it is based on the idea that variation in a quantitative trait is influenced by an infinitely large number of genes, each of which makes an infinitely small (infinitesimal) contribution to ...