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Additionally, scientists discovered that participants who were heavy cannabis users also had reduced brain activity in certain areas of the brain, including the dorsolateral prefrontal cortex ...
Cannabis plants vary widely, with different strains producing dynamic balances of cannabinoids (THC, CBD, etc.) and yielding markedly different effects. Popular strains are often hybrids of C. sativa and C. indica. The medicinal effects of cannabis are widely studied, and are active topics of research both at universities and private research ...
A dried cannabis flower. The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol, and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.
However, tolerance to psilocybin is a well understood concept, with repeatedly higher doses being needed in order to achieve the same effect, due to the down regulation of 5HT2A receptors. [6] There is also documented cross-tolerance between psilocybin and LSD, meaning that a higher dose of these substances is needed to get the same effect when ...
The entourage effect is a hypothesis that cannabis compounds other than tetrahydrocannabinol (THC) act synergistically with it to modulate the overall psychoactive effects of the plant. [ 1 ] [ 2 ] The effect has also been applied in the case of psilocybin mushrooms , with other compounds besides psilocybin having been hypothesized to also ...
The effects last for two to six hours, depending on the amount used. At high doses, mental effects can include anxiety, delusions (including ideas of reference), hallucinations, panic, paranoia, and psychosis. There is a strong relation between cannabis use and the risk of psychosis, though the direction of causality is debated.
Some users report mild "jitters" (body tremors), shuddering breath, and/or mild muscle spasms after insufflating 2C-B. Whether or not these effects are enjoyable depends on the user; Mild to intense diarrhea, gas, nausea, and general gastrointestinal discomfort; Severe headaches after coming down from large doses have been reported.
The presence of these specialized cannabinoid receptors in the brain led researchers to the discovery of endocannabinoids, such as anandamide and 2-arachidonoyl glyceride . [citation needed] THC is a lipophilic molecule [27] and may bind non-specifically to a variety of entities in the brain and body, such as adipose tissue (fat).