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  2. CHEK2 - Wikipedia

    en.wikipedia.org/wiki/CHEK2

    The estimated fraction of breast cancer attributed to this variant is reported to be around 1.2% in the US. [ 8 ] Two more CHEK2 gene mutations, CHEK2*S428F, an amino-acid substitution to the kinase domain in exon 11 and CHEK2*P85L, an amino-acid substitution in the N-terminal region (exon 1) have been found in the Ashkenazi Jewish population ...

  3. Guidelines say more women may need breast cancer gene test - AOL

    www.aol.com/news/2019-08-26-guidelines-say-more...

    Most cancer isn't caused by BRCA mutations — they account for 5 percent to 10 percent of breast cancers and 15 percent of ovarian cancers — so the gene tests aren't for everyone. But mutations ...

  4. BRCA mutation - Wikipedia

    en.wikipedia.org/wiki/BRCA_mutation

    Compared to that, a woman with a high-risk BRCA1 mutation, if she had breast cancer screening but no prophylactic medical or surgical intervention, would have only 59% chance to reach age 70, twenty-five percentage points lower than normal. Of those women not surviving, 26% would die of breast cancer, 46% ovarian cancer, and 28% other causes. [15]

  5. BRCA2 - Wikipedia

    en.wikipedia.org/wiki/BRCA2

    A patent application for the isolated BRCA1 gene and cancer-cancer promoting mutations, as well as methods to diagnose the likelihood of getting breast cancer, was filed by the University of Utah, National Institute of Environmental Health Sciences (NIEHS) and Myriad Genetics in 1994; [42] over the next year, Myriad, in collaboration with other ...

  6. New blood test can spot breast cancer at earliest ... - AOL

    www.aol.com/blood-test-spot-breast-cancer...

    Researchers said the fast and non-invasive technique could pave the way for a screening test for multiple forms of cancer. New blood test can spot breast cancer at earliest stages, say scientists ...

  7. Hereditary breast–ovarian cancer syndrome - Wikipedia

    en.wikipedia.org/wiki/Hereditary_breast–ovarian...

    Absolute risk of cancers in BRCA1 or BRCA2 mutation. [4]A number of genes are associated with HBOC. [5] The most common of the known causes of HBOC are: BRCA mutations: [5] Harmful mutations in the BRCA1 and BRCA2 genes can produce very high rates of breast and ovarian cancer, as well as increased rates of other cancers.

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