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Large-cell lung carcinoma (LCLC), or large-cell carcinoma (LCC) in short, is a heterogeneous group of undifferentiated malignant neoplasms that lack the cytologic and architectural features of small cell carcinoma and glandular or squamous differentiation. [1]
While undifferentiated large-cell lung carcinoma is the most common parent lung tumor from which a rhabdoid phenotype evolves, [21] malignant cells with a rhabdoid phenotype are known to occur in many different histological variants of lung cancer, including adenocarcinoma, [22] sarcomatoid carcinoma, [23] [22] squamous cell carcinoma, [24 ...
Large-cell neuroendocrine carcinoma of the lung (LCNEC of the lung), or pulmonary large-cell neuroendocrine carcinoma (PLCNC), is a highly malignant neoplasm arising from transformed epithelial cells originating in tissues within the pulmonary tree. It is currently considered to be a subtype of large-cell lung carcinoma.
Giant-cell carcinoma of the lung; Large-cell lung carcinoma; Large cell lung carcinoma with rhabdoid phenotype; Laryngeal cancer; Mesothelioma; Non-small cell lung cancer; Non-small cell lung carcinoma; Pleuropulmonary blastoma; Sarcomatoid carcinoma of the lung; Small cell lung cancer; Squamous-cell carcinoma of the lung; Thymoma and thymic ...
In the large 1995 database review by Travis and colleagues, giant-cell carcinoma has the third-worst prognosis among 18 histological forms of lung cancer. (Only small-cell carcinoma and large-cell carcinoma had shorter average survival.) [5]
Large cell carcinoma Composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm. Small cell carcinoma Cells are usually round and are less than approximately three times the diameter of a resting lymphocyte and with little evident cytoplasm. Occasionally, small cell malignancies may themselves have ...
Around 15% of cases are small-cell lung cancer (SCLC), and the remaining 85% (the non-small-cell lung cancers or NSCLC) are adenocarcinomas, squamous-cell carcinomas, and large-cell carcinomas. After diagnosis, further imaging and biopsies are done to determine the cancer's stage based on how far it has spread.
Micrograph showing large cells. H&E stain. Large cell is a term used in oncology. It does not refer to a particular type of cell; rather it refers to cells that are larger than would be normally expected for that type. It is frequently used when describing lymphoma and lung cancer.
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