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The user specifies the alternative hypothesis in terms of differing response rates, means, survival times, relative risks, or odds ratios. Matched or independent study designs may be used. Power, sample size, and the detectable alternative hypothesis are interrelated.
The sample size is an important feature of any empirical study in which the goal is to make inferences about a population from a sample. In practice, the sample size used in a study is usually determined based on the cost, time, or convenience of collecting the data, and the need for it to offer sufficient statistical power. In complex studies ...
nQuery is a clinical trial design platform used for the design and monitoring of adaptive, group sequential, and fixed sample size trials. It is most commonly used by biostatisticians to calculate sample size and statistical power for adaptive clinical trial design. nQuery is proprietary software developed and distributed by Statsols. The ...
The response factor can be expressed on a molar, volume or mass [1] basis. Where the true amount of sample and standard are equal: = where A is the signal (e.g. peak area) and the subscript i indicates the sample and the subscript st indicates the standard. [2]
The IC 50 of a drug can be determined by constructing a dose-response curve and examining the effect of different concentrations of antagonist on reversing agonist activity. IC 50 values can be calculated for a given antagonist by determining the concentration needed to inhibit half of the maximum biological response of the agonist. [ 4 ]
The sample covariance matrix (SCM) is an unbiased and efficient estimator of the covariance matrix if the space of covariance matrices is viewed as an extrinsic convex cone in R p×p; however, measured using the intrinsic geometry of positive-definite matrices, the SCM is a biased and inefficient estimator. [1]
Like approximate entropy (ApEn), Sample entropy (SampEn) is a measure of complexity. [1] But it does not include self-similar patterns as ApEn does. For a given embedding dimension, tolerance and number of data points, SampEn is the negative natural logarithm of the probability that if two sets of simultaneous data points of length have distance < then two sets of simultaneous data points of ...
If the response data used to estimate the model contain values that change sign, or if the lowest response value is far from zero (for example, when data are left-truncated), a location parameter, L, may be added to the response so that the expressions for the quantile function and for the median become, respectively: