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Belimumab, sold under the brand name Benlysta, is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), [6] also known as B-lymphocyte stimulator (BLyS). [7] It is approved in the United States [ 8 ] and Canada, [ 9 ] and the European Union [ 5 ] to treat systemic lupus erythematosus and lupus nephritis.
The US Food and Drug Administration (FDA) granted the application for belantamab mafodotin priority review, orphan drug, and breakthrough therapy designations. [ 5 ] In 2023, the confirmatory phase III DREAMM-3 trial aimed to compare belantamab mafodotin versus pomalidomide plus low-dose dexamethasone in participants with relapsed or refractory ...
The primary teeth were not in direct contact with the underlying dentigerous cyst. It has been suggested that dentigerous cysts may be either extrafollicular or intrafollicular in origin. There were three possible mechanisms exist. Firstly, surrounding the crowns of affected teeth, the intrafollicular developmental dentigerous cysts may be formed.
In addition to periapical abscesses, periapical periodontitis can give rise to various related lesions, including periapical granulomas and cysts. [11] A periapical granuloma (also referred to as an 'apical granuloma' or 'radicular granuloma') is a mass of chronically inflamed granulation tissue that forms at the apex of the root of a nonvital ...
A 2016 systematic review indicated that using toothpaste when brushing the teeth does not necessarily impact the level of plaque removal. [10] However, the active ingredients in toothpastes are able to prevent dental diseases with regular use.
This has resulted in many subtypes and new systems (see section below: Review of Angle's system of classes). A deep bite (also known as a Type II Malocclusion) is a condition in which the upper teeth overlap the lower teeth, which can result in hard and soft tissue trauma, in addition to an effect on appearance. [26]
A systematic review concluded that for decayed baby (primary) teeth, putting an off‐the‐shelf metal crown over the tooth (Hall technique) or only partially removing decay (also referred to as "selective removal" [5]) before placing a filling may be better than the conventional treatment of removing all decay before filling. [6]
It can affect people of any age, although those aged 20–50 years are more likely to be affected. [3] Females are slightly more likely to develop dentin hypersensitivity compared to males. [ 3 ] The condition is most commonly associated with the maxillary and mandibular canine and bicuspid teeth on the facial (buccal) aspect, [ 3 ] especially ...