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As with other GLP-1 receptor agonists, the most common side effects of semaglutide reported during the Wegovy clinical trials include things like: Nausea. Vomiting. Diarrhea. Constipation ...
Some patients develop anti-drug antibodies, which are more common with exenatide (the antibodies were detectable in a third or more of patients) than other GLP-1 agonists and can decrease the drug's efficacy. [29] GLP-1 agonists increase the risk of gallstones when used to induce rapid weight loss. [15]
GLP-1 agonists are a class of medications that mimic the action of the hormone GLP-1 (glucagon-like peptide-1), which is involved in insulin production and appetite regulation. “GLP-1 stands for ...
Your prescribing healthcare provider can make sure this GLP-1 (glucagon-like peptide-1) agonist drug is safe for you. If not, they can recommend an alternative weight loss drug.
Tirzepatide, a dual agonist of GLP-1 and GIP receptors, is approved for type 2 diabetes and obesity.With an average 20 percent weight loss at a high dosage, it appears to be more effective than GLP-1 mono agonists although there have been no head to head trials as of 2023.
In accordance with the expression of GLP-1 receptor on brainstem and hypothalamus, GLP-1 has been shown to promote satiety and thereby reduce food and water intake. Consequently, diabetic subjects treated with GLP-1 receptor agonists often experience weight loss as opposed to the weight gain commonly induced with other treatment agents. [2] [15]
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