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  2. FASTA format - Wikipedia

    en.wikipedia.org/wiki/FASTA_format

    Thus, the examples above would be a multi-FASTA file if taken together. Modern bioinformatics programs that rely on the FASTA format expect the sequence headers to be preceded by ">". The sequence is generally represented as "interleaved", or on multiple lines as in the above example, but may also be "sequential", or on a single line.

  3. File:Example.pdf - Wikipedia

    en.wikipedia.org/wiki/File:Example.pdf

    Short title: example derived form Ghostscript examples: Image title: derivative of Ghostscript examples "text_graphic_image.pdf", "alphabet.ps" and "waterfal.ps"

  4. FASTQ format - Wikipedia

    en.wikipedia.org/wiki/FASTQ_format

    The FAST4 format was invented as a derivative of the FASTQ format where each of the 4 bases (A,C,G,T) had separate probabilities stored. It was part of the Swift basecaller, an open source package for primary data analysis on next-gen sequence data "from images to basecalls". The FAST5 format was invented as an extension of the FAST4 format.

  5. Sequence alignment - Wikipedia

    en.wikipedia.org/wiki/Sequence_alignment

    It has been shown that, given the structural alignment between a target and a template sequence, highly accurate models of the target protein sequence can be produced; a major stumbling block in homology-based structure prediction is the production of structurally accurate alignments given only sequence information. [22]

  6. FASTA - Wikipedia

    en.wikipedia.org/wiki/FASTA

    The original FASTA program was designed for protein sequence similarity searching. Because of the exponentially expanding genetic information and the limited speed and memory of computers in the 1980s heuristic methods were introduced aligning a query sequence to entire data-bases.

  7. Transcription activator-like effector nuclease - Wikipedia

    en.wikipedia.org/wiki/Transcription_activator...

    Workflow of genome editing of Your Favorite Gene (YFG) using TALEN. The target sequence is identified, a corresponding TALEN sequence is engineered and inserted into a plasmid. The plasmid is inserted into the target cell where it is translated to produce the functional TALEN, which enters the nucleus and binds and cleaves the target sequence.

  8. Allele-specific oligonucleotide - Wikipedia

    en.wikipedia.org/wiki/Allele-specific_oligo...

    An anti-sense oligonucleotide (ASO) is a short piece of synthetic DNA complementary to the sequence of a variable target DNA. It acts as a probe for the presence of the target in a Southern blot assay or, more commonly, in the simpler dot blot assay. It is a common tool used in genetic testing, forensics, and molecular biology research.

  9. Biological target - Wikipedia

    en.wikipedia.org/wiki/Biological_target

    The term "biological target" is frequently used in pharmaceutical research to describe the native protein in the body whose activity is modified by a drug resulting in a specific effect, which may be a desirable therapeutic effect or an unwanted adverse effect. In this context, the biological target is often referred to as a drug target.