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If pregnant women could be given a vaccine against GBS, this could potentially prevent most cases of GBS without the need for antibiotics or screening. Vaccination is considered an ideal solution to prevent not only early- and late-onset disease but also GBS infections in adults at risk.
GBS is a normal component of the intestinal and vaginal microbiota in some people, GBS is an asymptomatic (presenting no symptoms) colonizer of the gastrointestinal tract and vagina in up to 30% of otherwise healthy adults, including pregnant women. [3] [15] GBS colonization may be permanent
S. agalactiae, or group B streptococcus, GBS, causes pneumonia and meningitis in newborns and the elderly, with occasional systemic bacteremia. Importantly, Streptococcus agalactiae is the most common cause of meningitis in infants from one month to three months old.
Hafner E, Sterniste W, Rosen A, et al. Group B streptococci during pregnancy: a comparison of two screening and treatment protocols. Am J Obstet Gynecol 1998; 179:677--81. ^ Antimicrobial prevention of early-onset group B streptococcal sepsis: estimates of risk reduction based on a critical literature review Benitz WE, Gould JB, Druzin ML ...
Her research has impacted public health by leading to the adoption of routine screening and antibiotic prophylaxis for pregnant women to prevent early-onset GBS disease in newborns. This intervention has reduced GBS infection rates in newborns. [3] Baker has been appointed as the Global Vaccine Engagement Adviser for Group B Strep Support. [4]
Freya Murphy died aged seven days in July 2018 in the Queen Elizabeth University Hospital in Glasgow, a fatal accident inquiry heard.
The charity has been heavily involved in public consultations on group B Strep prevention, and in 2012 commented on the National Screening Committee's review of GBS testing. [3] In 2012, the chief executive Jane Plumb received an MBE for services for child health.
Group B streptococcus (GBS), also named Streptococcus agalactiae, is a bacteria typically identified as the cause of the majority of early-onset infections in the neonate. GBS is an encapsulated gram-positive cocci that colonizes the gastrointestinal and genital tracts of pregnant women. Maternal infections are usually asymptomatic.