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A neuromuscular non-depolarizing agent is a form of neuromuscular blocker that does not depolarize the motor end plate. [8] The quaternary ammonium muscle relaxants belong to this class. Quaternary ammonium muscle relaxants are quaternary ammonium salts used as drugs for muscle relaxation, most commonly in anesthesia.
Drug-induced comas are used to protect the brain during major neurosurgery, as a last line of treatment in certain cases of status epilepticus that have not responded to other treatments, [2] and in refractory intracranial hypertension following traumatic brain injury. [1] Induced coma usually results in significant systemic adverse effects.
[9] [10] He was the first to show that curare does not kill the animal and the recovery is complete if the animal's respiration is maintained artificially. In 1825, Charles Waterton described a classical experiment in which he kept a curarized female donkey alive by artificial respiration with a bellows through a tracheostomy . [ 11 ]
Cadaveric spasm is seen in cases of drowning victims when grass, weeds, roots or other materials are clutched, and provides evidence of life at the time of entry into the water. Cadaveric spasm often crystallizes the last activity one did before death and is therefore significant in forensic investigations, e.g. holding onto a knife tightly. [4]
Suxamethonium chloride (brand names Scoline and Sucostrin, among others), also known as suxamethonium or succinylcholine, or simply sux in medical abbreviation, [5] is a medication used to cause short-term paralysis as part of general anesthesia. [6]
Paralysis (pl.: paralyses; also known as plegia) is a loss of motor function in one or more muscles.Paralysis can also be accompanied by a loss of feeling (sensory loss) in the affected area if there is sensory damage.
A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone.It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia.
Effects are greatest at about 4 minutes and last for up to an hour. [2] Side effects may include low blood pressure and prolonged paralysis. [4] Allergic reactions are rare. [5] It is unclear if use in pregnancy is safe for the baby. [2] Vecuronium is in the aminosteroid neuromuscular-blocker family of medications and is of the non-depolarizing ...