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Feet of a baby born to a mother who had taken thalidomide while pregnant. In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as ...
“Today, on behalf of the people of Australia, our government and this Parliament offers a full unreserved and overdue apology to all thalidomide survivors, their families, loved ones, and carers ...
Thalidomide was the active ingredient in a sedative widely distributed to many mothers in Australia and around the world in the early 1960s. ... The thalidomide scandal triggered a worldwide ...
‘The thalidomide tragedy is a dark chapter in the history of our nation and the world’ Australia to issue national apology to citizens affected by ‘Thalidomide birth defects’ Skip to main ...
Thalidomide is racemic; while S-thalidomide is the bioactive form of the molecule, the individual enantiomers can racemize to each other due to the acidic hydrogen at the chiral centre, which is the carbon of the glutarimide ring bonded to the phthalimide substituent. The racemization process can occur in vivo.
Thalidomide scandal: International: Mostly US and Europe 1950s-60s Thalidomide was given to people, including pregnant women, resulting in severe birth deformities and miscarriages. Despite not receiving FDA approval in the US, thalidomide was given to many women as part of clinical trials without their consent or awareness. [17]
By Steven Brill What Happened in the Previous Chapter ‘Otherwise The Sky Would Be The Limit’ In 1961, newspapers around the world ran stories (accompanied by horrific images) of deformed babies whose mothers had taken a drug to curb nausea during pregnancy called thalidomide. A vigilant FDA inspector had refused to approve thalidomide for ...
McBride published a letter in The Lancet, in December 1961, noting a large number of birth defects in children of patients who were prescribed thalidomide, [9] after a midwife named Sister Pat Sparrow first suspected the drug was causing birth defects in the babies of patients under his care at Crown Street Women's Hospital in Sydney. [10]