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  2. Thalidomide scandal - Wikipedia

    en.wikipedia.org/wiki/Thalidomide_scandal

    Feet of a baby born to a mother who had taken thalidomide while pregnant. In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as ...

  3. America’s Most Admired Lawbreaker - The Huffington Post

    highline.huffingtonpost.com/miracleindustry/...

    By Steven Brill What Happened in the Previous Chapter ‘Otherwise The Sky Would Be The Limit’ In 1961, newspapers around the world ran stories (accompanied by horrific images) of deformed babies whose mothers had taken a drug to curb nausea during pregnancy called thalidomide. A vigilant FDA inspector had refused to approve thalidomide for ...

  4. Frances Oldham Kelsey - Wikipedia

    en.wikipedia.org/wiki/Frances_Oldham_Kelsey

    Frances Kathleen Oldham Kelsey CM (née Oldham; July 24, 1914 – August 7, 2015) was a Canadian-American [1] pharmacologist and physician. As a reviewer for the U.S. Food and Drug Administration (FDA), she refused to authorize thalidomide for market because she had concerns about the lack of evidence regarding the drug's safety. [2]

  5. Thalidomide - Wikipedia

    en.wikipedia.org/wiki/Thalidomide

    Thalidomide is racemic; while S-thalidomide is the bioactive form of the molecule, the individual enantiomers can racemize to each other due to the acidic hydrogen at the chiral centre, which is the carbon of the glutarimide ring bonded to the phthalimide substituent. The racemization process can occur in vivo.

  6. Grünenthal - Wikipedia

    en.wikipedia.org/wiki/Grünenthal

    In November 1961, thalidomide was thus taken off the market. [11] [12] Thalidomide caused severe deformities in the children of women who took the drug during pregnancy. Experts estimate that the drug thalidomide led to the death of about 2,000 children and serious birth defects in more than 10,000 children, about 5,000 of them in West Germany.

  7. Australia to apologise half a century after 'Thalidomide tragedy'

    www.aol.com/news/australia-apologise-half...

    The thalidomide scandal triggered a worldwide overhaul of drug-testing regimes and boosted the reputation of the U.S. Food and Drug Administration, which proved a lone voice in refusing to approve ...

  8. Heinrich Mückter - Wikipedia

    en.wikipedia.org/wiki/Heinrich_Mückter

    Thalidomide was eventually found to cause miscarriages, severe birth defects in babies whose mothers had taken the medication while pregnant, and severe nerve damage. [1] [failed verification] [2] In January 1968, Mückter was put on trial along with other Grünenthal employees. The trial ended abruptly in April 1970 with a settlement ...

  9. Australia apologizes for thalidomide tragedy as some ...

    www.aol.com/news/australia-apologizes...

    Survivors of the harmful morning sickness drug thalidomide were in the public gallery Wednesday when Australia’s Parliament made a national apology to them on the 62nd anniversary of the drug ...