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2. Nitric oxide synthase - Wikipedia

   en.wikipedia.org/wiki/Nitric_oxide_synthase

   Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). [2] The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired ...

3. Endothelium-derived relaxing factor - Wikipedia

   en.wikipedia.org/wiki/Endothelium-derived...

   EDRF is produced from L-arginine by an enzyme (endothelial nitric oxide synthase) that is dependent on calcium-calmodulin and NADPH - this occurs in the cardiac endothelium. [citation needed] EDRF then diffuses to the smooth muscle in vascular tissue (vessels may be large or small), here it enacts endogenous vasodilation. Moreover, it serves ...

4. Biological functions of nitric oxide - Wikipedia

   en.wikipedia.org/wiki/Biological_functions_of...

   Nitric oxide is generated by phagocytes (monocytes, macrophages, and neutrophils) as part of the human immune response. [26] Phagocytes are armed with inducible nitric oxide synthase (iNOS), which is activated by interferon-gamma (IFN-γ) as a single signal or by tumor necrosis factor (TNF) along with a second signal.

5. NOS1 - Wikipedia

   en.wikipedia.org/wiki/NOS1

   Nitric oxide synthase 1 (neuronal), also known as NOS1, is an enzyme that in humans is encoded by the NOS1 gene. [5] [6] Function. Nitric oxide synthases (EC 1.14.13 ...

6. Endothelial NOS - Wikipedia

   en.wikipedia.org/wiki/Endothelial_NOS

   Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene located in the 7q35-7q36 region of chromosome 7. [5]

7. Plasma membrane Ca2+ ATPase - Wikipedia

   en.wikipedia.org/wiki/Plasma_membrane_Ca2+_ATPase

   Isoform PMCA4b interacts with nitric oxide synthase and reduces synthesis of nitric oxide by that enzyme. [12] PMCA isoform 4 has a molecular weight of 134,683, calculated from its sequence. [13] This is in good agreement with the results of SDS gel electrophoresis. [14]