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Eosinophilic cellulitis, also known as Wells' syndrome (not to be confused with Weil's disease), is a skin disease that presents with painful, red, raised, and warm patches of skin. [2] The rash comes on suddenly, lasts for a few weeks, and often repeatedly comes back. [2] Scar formation does not typically occur. [1]
Muckle–Wells syndrome (MWS) is a rare autosomal dominant disease which causes sensorineural deafness and recurrent hives, and can lead to amyloidosis. Individuals with MWS often have episodic fever, chills, and joint pain. As a result, MWS is considered a type of periodic fever syndrome.
Major symptoms of Hay–Wells syndrome include: sparse hair and eyelashes, missing teeth, cleft palate, cleft lip with fusing of the upper and lower eyelids, and deformed nails. [ 5 ] [ 22 ] Therefore, a diagnosis of Hay–Wells syndrome is largely based upon the physical clinical presentation of the patient.
It encompasses a spectrum of three clinically overlapping autoinflammatory syndromes including familial cold autoinflammatory syndrome (FCAS, formerly termed familial cold-induced urticaria), the Muckle–Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease (NOMID, also called chronic infantile neurologic cutaneous and ...
Mowat–Wilson syndrome; Moyamoya disease; Moynahan syndrome; Muckle–Wells syndrome; Muenke syndrome; Muir–Torre syndrome; Mukamel syndrome; Multiple endocrine neoplasia type 1; Multiple endocrine neoplasia type 2; Multiple evanescent white dot syndrome; Multiple hamartoma syndrome; Multiple organ dysfunction syndrome; Multiple pterygium ...
Wilkie–Taylor–Scambler syndrome; Willebrand disease, acquired; Willebrand disease; Willems–De vries syndrome; Williams syndrome; Wilms' tumor; Wilms tumor and pseudohermaphroditism; Wilms tumor radial bilateral aplasia; Wilms tumor-aniridia syndrome; Wilson's disease; Wilson–Turner syndrome; Winchester syndrome; Winkelman–Bethge ...
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The disease is caused in 60% of cases by a mutated gene called CIAS1 that is known to be involved in other syndromes that appear somewhat similar, such as Muckle–Wells syndrome and familial cold urticaria. In many patients, the parents do not have the same mutation, indicating the problem was not inherited, even though it is a genetic disease.