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The most common adverse reactions include fatigue, musculoskeletal pain, rash, diarrhea, hypothyroidism, constipation, nausea, headache, pruritis, edema, localized infection, and urinary tract infection. [2] Cosibelimab was approved for medical use in the United States in December 2024. [1] [2] [3] [4]
Zanidatamab, sold under the brand name Ziihera, is a humanized monoclonal antibody used for the treatment of HER2-positive biliary tract cancer. [1] [2] It is an IgG-like bispecific HER2-directed antibody directed against two non-overlapping domains of HER2.
The case where μ = 0 and β = 1 is called the standard fatigue life distribution.The pdf for the standard fatigue life distribution reduces to = + >; >Since the general form of probability functions can be expressed in terms of the standard distribution, all of the subsequent formulas are given for the standard form of the function.
Some English examples result from nouns being verbed in the patterns of "add <noun> to" and "remove <noun> from"; e.g. dust, seed, stone. Denotations and connotations can drift or branch over centuries.
The fatigue allowance is intended to cover the time that the worker should be given to overcome fatigue due to work related stress and conditions. There are three factors that cause fatigue: (1) physical factors like standing and use of force, (2) mental and cognitive factors like mental strain and eye strain , and (3) environmental and work ...
The term antonym (and the related antonymy) is commonly taken to be synonymous with opposite, but antonym also has other more restricted meanings. Graded (or gradable) antonyms are word pairs whose meanings are opposite and which lie on a continuous spectrum (hot, cold).
Fatigue in a medical context is used to cover experiences of low energy that are not caused by normal life. [2] [3]A 2021 review proposed a definition for fatigue as a starting point for discussion: "A multi-dimensional phenomenon in which the biophysiological, cognitive, motivational and emotional state of the body is affected resulting in significant impairment of the individual's ability to ...
Fatigue can be both physical and mental. Physical fatigue is the inability to continue functioning at the level of one's normal abilities; a person with physical fatigue cannot lift as heavy a box or walk as far as he could if not fatigued. [3] [4] [5] Mental fatigue, on the other hand, rather manifests in sleepiness or slowness. A person with ...