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Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time."
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In humans, N-demethylation of oxycodone to noroxycodone by CYP3A4 is the major metabolic pathway, accounting for 45% ± 21% of a dose of oxycodone, while O-demethylation of oxycodone into oxymorphone by CYP2D6 and 6-ketoreduction of oxycodone into 6-oxycodols represent relatively minor metabolic pathways, accounting for 11% ± 6% and 8% ± 6% ...
Ethylmorphine [2] 9059 opiate Etorphine hydrochloride [4] 9640 opiate Granulated opium [2] 9193 opiate Hydrocodone [2] 9150 opiate Hydromorphone [2] 9260 opiate Metopon [2] 9300 opiate Morphine [2] 9668 opiate Noroxymorphone [5] 9610 opiate Opium extracts [2] 9620 opiate Opium fluid [2] 9330 opiate Oripavine [6] 9143 opiate Oxycodone [2] 9652 ...
Printable version; In other projects ... [25] Other opioids are semi-synthetic and synthetic drugs such as hydrocodone, oxycodone, ... 2.5: 137: 223 [182 ...
The list will be alphabetical and will use the following format (subject to change if better suggestions are put forward). All items in the list will follow the general format: Name of drug (who calls it that) [country]. Redirects to name of drug.
See also the list of the top 100 bestselling branded drugs, ranked by sales. Abbreviations are used in the list as follows: INN = International Nonproprietary Name; BAN = British Approved Name; USAN = United States Adopted Name; Two-letter codes for countries
Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.