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[3] [10] [9] Many papain-like protease enzymes function as monomers, though a few, such as cathepsin C (Dipeptidyl-peptidase I), are homotetramers. The mature monomer structure is characteristically divided into two lobes or subdomains, known as the L-domain and the R-domain , where the active site is located between them. [1]
The cysteine cathepsins have attracted significant research effort as drug targets. [1] [2] Cancer, Cathepsin D is a mitogen and "it attenuates the anti-tumor immune response of decaying chemokines to inhibit the function of dendritic cells". Cathepsins B and L are involved in matrix degradation and cell invasion. [3] Stroke [4] Traumatic brain ...
Cathepsin L1 is a protein that in humans is encoded by the CTSL1 gene. [ 3 ] [ 4 ] [ 5 ] The protein is a cysteine cathepsin , a lysosomal cysteine protease that plays a major role in intracellular protein catabolism .
Cathepsin L may refer to: Cathepsin L1, a human protease enzyme encoded by the CTSL gene and known for its role in viral entry; Cathepsin L2, a human protease enzyme ...
Papain, also known as papaya proteinase I, is a cysteine protease (EC 3.4.22.2) enzyme present in papaya (Carica papaya) and mountain papaya (Vasconcellea cundinamarcensis).It is the namesake member of the papain-like protease family.
Ribbon diagram of a protease (TEV protease) complexed with its peptide substrate in black with catalytic residues in red.(. A protease (also called a peptidase, proteinase, or proteolytic enzyme) [1] is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products. [2]
1515 13039 Ensembl ENSG00000136943 ENSMUSG00000021477 UniProt O60911 P06797 RefSeq (mRNA) NM_001333 NM_001201575 NM_009984 RefSeq (protein) NP_001188504 NP_001324 NP_034114 Location (UCSC) Chr 9: 97.03 – 97.16 Mb Chr 13: 64.51 – 64.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cathepsin L2 (EC 3.4.22.43, also known as cathepsin V or cathepsin U) is a protein encoded in ...
The activity of cysteine proteases is regulated by a few general mechanisms, which includes the production of zymogens, selective expression, pH modification, cellular compartmentalization, and regulation of their enzymatic activity by endogenous inhibitors, which seemingly is the most efficient mechanism associated with the regulation of the ...