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Mitochondrial biogenesis is the process by which cells increase mitochondrial numbers. [1] [2] It was first described by John Holloszy in the 1960s, when it was discovered that physical endurance training induced higher mitochondrial content levels, leading to greater glucose uptake by muscles. [3]
Download as PDF; Printable version ... A mitogen is a small bioactive protein or ... as some growth factors instead appear to cause mitogenic effects ...
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The first mitogen-activated protein kinase to be discovered was ERK1 in mammals. Since ERK1 and its close relative ERK2 are both involved in growth factor signaling, the family was termed "mitogen-activated". With the discovery of other members, even from distant organisms (e.g. plants), it has become increasingly clear that the name is a ...
VEGF xxx may then cause the creation of new blood vessels in the retina and elsewhere in the eye, heralding changes that may threaten the sight. VEGF-A plays a role in the disease pathology of the wet form age-related macular degeneration (AMD), which is the leading cause of blindness for the elderly of the industrialized world. The vascular ...
53608 Ensembl ENSG00000142733 ENSMUSG00000028862 UniProt O95382 Q9WTR2 RefSeq (mRNA) NM_001297609 NM_004672 NM_145319 NM_016693 RefSeq (protein) NP_001284538 NP_004663 NP_057902 Location (UCSC) Chr 1: 27.35 – 27.37 Mb Chr 4: 132.97 – 132.98 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitogen-activated protein kinase kinase kinase 6 is a protein that in humans is encoded by ...
Growth factor is sometimes used interchangeably among scientists with the term cytokine. [3] Historically, cytokines were associated with hematopoietic (blood and lymph forming) cells and immune system cells (e.g., lymphocytes and tissue cells from spleen, thymus, and lymph nodes).
Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK). MAP2K is classified as EC 2.7.12.2 .