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Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
Dose optimization and target attainment of vancomycin in children involves adjusting the dosage to maximize effectiveness while minimizing the risk of adverse effects, specifically acute kidney injury. Dose optimization is achieved by therapeutic drug monitoring (TDM), which allows measurement of vancomycin levels in the blood.
MDCalc is a free online medical reference for healthcare professionals that provides point-of-care clinical decision-support tools, including medical calculators, scoring systems, and algorithms. [1] MDCalc is also a mobile and web app. [ 2 ] The decision-support tools are based on published clinical research, [ 3 ] and MDCalc’s content is ...
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
Not to be given to children and pregnant or lactating women. Similar structure with tetracycline, but five times stronger, big volume distribution and long half-time in the body Tinidazole: Tindamax Fasigyn: Protozoal infections: Upset stomach, bitter taste, and itchiness: Trimethoprim(Bs) Proloprim, Trimpex: Urinary tract infections: Generic ...
The fractional excretion of sodium (FE Na) is the percentage of the sodium filtered by the kidney which is excreted in the urine.It is measured in terms of plasma and urine sodium, rather than by the interpretation of urinary sodium concentration alone, as urinary sodium concentrations can vary with water reabsorption.
A drug of last resort (DoLR), also known as a heroic dose, [1] is a pharmaceutical drug which is tried after all other drug options have failed to produce an adequate response in the patient. Drug resistance , such as antimicrobial resistance or antineoplastic resistance , may make the first-line drug ineffective, especially in case of ...
In adults and children over the age of 12, linezolid is usually given every 12 hours, whether orally or intravenously. [54] [62] In younger children and infants, it is given every eight hours. [63] No dosage adjustments are required in the elderly, in people with mild-to-moderate liver failure, or in those with impaired kidney function. [64]