Search results
Results from the WOW.Com Content Network
Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation, growth, and survival of tumor cells. Though temsirolimus shows activity on its own, it is also known to be converted to sirolimus (rapamycin) in vivo; [4] therefore, its activity may be more attributed to its metabolite rather than the prodrug itself (despite claims to the ...
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
Description: English: Skeletal formula of sirolimus (brand name Rapamune) and temsirolimus (brand name Torisel) — mTOR inhibitors. Created with ChemDoodle and ...
PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. [1] AKT can have a number of downstream effects such as activating CREB , [ 2 ] inhibiting p27 , [ 3 ] localizing FOXO in the cytoplasm, [ 3 ] activating PtdIns -3ps, [ 4 ] and activating mTOR [ 3 ] which can affect transcription of p70 or 4EBP1. [ 3 ]
Description: English: Skeletal formula of temsirolimus (brand name Torisel) — an mTOR inhibitor. Created with ChemDoodle and Adobe Illustrator CC 2017. Date: 19 ...
ATC code L04 Immunosuppressants is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Main page; Contents; Current events; Random article; About Wikipedia; Contact us
The concept of the tumor microenvironment (TME) dates back to 1863 when Rudolf Virchow established a connection between inflammation and cancer. However, it was not until 1889 that Stephen Paget's seed and soil theory introduced the important role of TME in cancer metastasis, highlighting the intricate relationship between tumors and their surrounding microenvironment.