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2'-O-methylation (2'-O-Me) is a common nucleotide epitranscriptomics modification of ribosomal RNA (rRNA). The rRNA is transcribed from DNA and then used to create proteins through translation. [ 1 ] The resulting protein would normally be solely dependent on the gene it was translated from, but the methylation of the RNA would influence the ...
An unusual guide snoRNA U85 that functions in both 2′-O-ribose methylation and pseudouridylation of small nuclear RNA (snRNA) U5 has been identified. [14] This composite snoRNA contains both C/D and H/ACA box domains and associates with the proteins specific to each class of snoRNA (fibrillarin and Gar1p, respectively).
The eukaryotic messenger RNA, for example, is often methylated at the 2′-O position of the first and second nucleotide behind the 5′ cap. [12] These structures are termed cap1 and cap2 respectively. [13] MDA5 is able to detect the absence of the 2′-O-methylation, bind to this type of RNA and initiate an immune response. [14]
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] [2] In humans U29 and several other snoRNAs (U22 and U25-U31) are located in the introns of the same gene (called UHG for U22 host gene). [3] [4] U29 is proposed to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA ...
This snoRNA was originally cloned from HeLa cells and experimentally verified by northern blotting. [2] SNORD48 is predicted to guide the 2'O-ribose methylation of 28S rRNA C2279. [ 3 ] In the human genome this snoRNA is located in the introns of the same host gene (C6orf48) as another C/D box snoRNA U52 (also known as SNORD52).
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U25 is found in gene clusters in plants [2] and within the U22 snoRNA host gene (UHG) in mammals. [3] U25 is thought to as a 2'-O-ribose methylation guide for ribosomal RNA. This RNA has also been named snoRNA R73 in some plants.
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U32 is encoded within intron 2 of the ribosomal protein L13 gene in human and mouse [2] and is predicted to guide the 2'O-ribose methylation of both 18S ribosomal RNA (rRNA) residue G1328 and 28S rRNA residue A1511.
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] snoRNA U63 was purified from HeLa cells by immunoprecipitation with antifibrillarin antibody. It is predicted to guide the 2'-O-ribose methylation of 28s ribosomal RNA (rRNA) at residue A4531. [2]
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