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Phenacetin (/ f ɪ ˈ n æ s ɪ t ɪ n / ⓘ; acetophenetidin, N-(4-ethoxyphenyl)acetamide [1]) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. It was withdrawn from medicinal use as dangerous from the 1970s (e.g., withdrawn in Canada in 1973, [ 2 ] and by the U.S. Food and Drug ...
Trademarked in 1918, Anacin is one of the oldest brands of pain relievers in the United States. It originally contained acetophenetidin (phenacetin) and was promoted as "aspirin-free relief," but was reformulated in the 1980s following the FDA's ruling to withdraw phenacetin from the market in 1983 due to concerns over its carcinogenic ...
[1] In the Cowlairs district of Glasgow one such apothecary, named Adam Laidlaw, had a premises on Keppochhill Road. He devised a mix of aspirin, phenacetin and caffeine to combat colds, headaches and many other problems: a true panacea. By 1900, he was selling an average of 450 to 500 powders per week, and had obtained a fame somewhat wider ...
phenacetin; There is evidence that a compound of two analgesics with different mechanism of action can have an increased painkilling effect over the sum of the effect of each individual analgesic. [1] Several such formulations have disappeared from over-the-counter status in drug store aisles and other retail outlets.
It came in the form of APC (aspirin–phenacetin–caffeine) tablets or powder, containing 42% aspirin and 42% phenacetin plus caffeine. [1] Beckers Ltd - outside view of Bex building. Bex was a product of Beckers Pty Ltd, originally based at Pym Street, Dudley Park, South Australia, [2] but which relocated to Sydney in the 1960s. [3]
What is listed in Canada's set of Food and Drug Regulations [5] The name prescribed by another federal regulation; The name by which the food is formally known (for example: orange juice) The name of the product must also be displayed on the main label in both English and French with a minimum height of 1/16 of an inch (1.6 mm). [6]
Dr. Harry John Clayton (ca.1887 – 31 October 1928) [1] of Macquarie Street and medical superintendent of the Royal Prince Alfred Hospital, Sydney, took the headache remedy then in general use, composed of phenacetin and caffeine, and by experimenting with the addition of aspirin, arrived at what became the standard formulation known as A.P.C. powder, or in the Royal Prince Alfred Hospital ...
It is also used as a chemical intermediate in the manufacture of bucetin, phenacetin, ethoxyquin, and phenacaine. p-Phenetidine has high renal toxicity [3] and it is believed to be responsible for the adverse effects that led to the withdrawal of phenacetin and bucetin from pharmaceutical use. p-Phenetidine is also a possible mutagen. [4]
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