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In biology, the enzyme ITP3K is abbreviated a number of different ways, including 1D-myo-inositol-trisphosphate 3-kinase, ITP3K, ITPK, IP3-kinase, IP3-3-kinase, Ins(1,4,5)P3 3-kinase. In addition the enzyme may be named as the product of one of 3 genes in humans ITPKA , ITPKB , and ITPKC , or one of two in fruit flies, IP3K1 and IP3K2 —a ...
Calcium signaling is the use of calcium ions (Ca 2+) to communicate and drive intracellular processes often as a step in signal transduction. Ca 2+ is important for cellular signalling , for once it enters the cytosol of the cytoplasm it exerts allosteric regulatory effects on many enzymes and proteins .
Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP 3 or Ins3P or IP 3 is an inositol phosphate signaling molecule. It is made by hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP 2), a phospholipid that is located in the plasma membrane, by phospholipase C (PLC).
IP3 is a secondary messenger that helps to send neuronal signals through the body. The neuronal cells have the calcium-signaling microdomains in the cytoplasm right next to the pre- and post-synaptic calcium channels in the nerve cells. Figure 1 is an example of how Na-K-ATPase forms the calcium-signaling microdomain.
3710 16440 Ensembl ENSG00000096433 ENSMUSG00000042644 UniProt Q14573 P70227 RefSeq (mRNA) NM_002224 NM_080553 RefSeq (protein) NP_002215 NP_542120 Location (UCSC) Chr 6: 33.62 – 33.7 Mb Chr 17: 27.28 – 27.34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene ...
For about 1% of those ages 50 to 79, test results will show a cancer signal was detected, along with the organ or tissue type associated with that specific cancer signal. An estimated 40% of these ...
Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca 2+ channel activated by inositol trisphosphate (InsP3). InsP3R is very diverse among organisms, and is necessary for the control of cellular and physiological processes including cell division, cell proliferation, apoptosis, fertilization, development, behavior, learning and memory. [2]
(See reference [13] for an illustration of the signaling cascade involving L-type calcium channels in smooth muscle). L-type calcium channels are also enriched in the t-tubules of striated muscle cells, i.e., skeletal and cardiac myofibers. When these cells are depolarized, the L-type calcium channels open as in smooth muscle.