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The term "biguanidine" often refers specifically to a class of drugs that function as oral antihyperglycemic drugs used for diabetes mellitus or prediabetes treatment. [4] Examples include: Metformin - widely used in treatment of diabetes mellitus type 2; Phenformin - withdrawn from the market in most countries due to toxic effects
Sterne was the first to try metformin on humans for the treatment of diabetes; he coined the name "Glucophage" (glucose eater) for the medication and published his results in 1957. [155] [162] Metformin became available in the British National Formulary in 1958. It was sold in the UK by a small Aron subsidiary called Rona. [163]
Although it must be used with caution in patients with impaired liver or kidney function, Metformin, a biguanide, has become the most commonly used agent for type 2 diabetes in children and teenagers. Among common diabetic drugs, Metformin is the only widely used oral drug that does not cause weight gain. [8]
Metformin helps manage blood sugar in people with type 2 diabetes in a few different ways: It helps the body respond better to the insulin it makes naturally, decreases the amount of sugar the ...
Metformin — a biguanide — is an oral diabetes medication that helps keep blood sugar in check by causing the liver to produce less glucose. It was approved by the FDA in 1994 for the treatment ...
One of the most common drugs used in T2D, metformin is the drug of choice to help patients lower their blood sugar levels. Metformin is an example of a class of medicine called biguanides. [34] The medication works by reducing the new creation of glucose from the liver and by reducing absorption of sugar from food. [34]
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