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This is termed the albumin/creatinine ratio (ACR) [10] and microalbuminuria is defined as ACR ≥3.5 mg/mmol (female) or ≥2.5 mg/mmol (male), [11] or with both substances measured by mass, as an ACR between 30 and 300 μg albumin/mg creatinine. [12] For the diagnosis of microalbuminuria, care must be taken when collecting sample for the urine ...
Measurement Lower limit Upper limit Unit Urinary specific gravity: 1.003 [1] [2]: 1.030 [1] [2]: g/mL Urobilinogen: 0.2 [2]: 1.0 [2]: Ehrlich units or mg/dL : Free catecholamines, dopamine ...
Creatinine(U)] is taken into account due to the notion that creatinine is normally released into the urine at a constant rate. [6] Scientists found that the ratio of protein to creatinine roughly estimates the actual value gained from the 24-hour urine protein test. [6] The normal urine protein/creatinine ratio is less than 200 mg/g. [7]
A1 represents normal to mildly increased urinary albumin/creatinine ratio (<30 mg/g or < 3 mg/mmol); A2 represents moderately increased urinary albumin/creatinine ratio (30–300 mg/g or 3–30 mg/mmol, previously known as microalbuminuria); and A3 reflects severely increased urinary albumin/creatinine ratio >300 mg/g or > 30 mg/mmol).
Proteinuria is defined as a protein/creatinine ratio greater than 45 mg/mmol (which is equivalent to albumin/creatinine ratio of greater than 30 mg/mmol or approximately 300 mg/g) with very high levels of proteinuria having a ratio greater than 100 mg/mmol. [23]
It normally ranges from 1.003 to 1.035; lower values indicate that the urine is dilute, while higher values mean that it is concentrated. A urine specific gravity that consistently remains around 1.010 ( isosthenuria ) can indicate kidney damage, as it suggests that the kidneys have lost the ability to control urine concentration. [ 39 ]
The typical human reference ranges for serum creatinine are 0.5 mg/dL to 1.0 mg/dL (about 45 μmol/L to 90 μmol/L) for women and 0.7 mg/dL to 1.2 mg/dL (60 μmol/L to 110 μmol/L) for men. The significance of a single creatinine value must be interpreted in light of the patient's muscle mass.
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