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Delayed onset muscle soreness (DOMS) is the pain and stiffness felt in muscles after unaccustomed or strenuous exercise. The soreness is felt most strongly 24 to 72 hours after the exercise. [1] [2]: 63 It is thought to be caused by eccentric (lengthening) exercise, which causes small-scale damage (microtrauma) to the muscle fibers. After such ...
Myotonia congenita is a congenital neuromuscular channelopathy that affects skeletal muscles (muscles used for movement). It is a genetic disorder.The hallmark of the disease is the failure of initiated contraction to terminate, often referred to as delayed relaxation of the muscles and rigidity. [1]
More severe rhabdomyolysis is characterized by muscle pain, tenderness, weakness and swelling of the affected muscles. [10] If the swelling is very rapid, as may happen with a crush injury after someone is released from under heavy collapsed debris, the movement of fluid from the bloodstream into damaged muscle may cause low blood pressure and ...
Brody disease (a disease of ion pump transport) has symptoms similar to myotonia congenita, however, the delayed muscle relaxation is pseudo-myotonia as the EMG is normal. [5] Other diseases that exhibit pseudo-myotonia are myositis , glycogen storage diseases , hyperkalemic periodic paralysis , root disease, anterior horn cell disorders ...
The drugs dantrolene and verapamil are used in BD treatment due to their effects on Ca 2+. [2] Dantrolene is a muscle relaxer that decreases the symptoms of BD by inhibiting Ca 2+ release channels in the sarcoplasmic reticulum, while verapamil sequesters Ca 2+ in the sarcoplasmic reticulum of muscle cells by functioning as a Ca 2+ channel blocker .
Myalgia or muscle pain is a painful sensation evolving from muscle tissue. It is a symptom of many diseases . The most common cause of acute myalgia is the overuse of a muscle or group of muscles ; another likely cause is viral infection , especially when there has been no injury .
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Early-delayed symptoms, occurring within the first months, typically include myelopathy. These issues frequently resolve without treatment. [20] Late-delayed symptoms, occurring several months or years after treatment, may also include myelopathy, but its severity level is more likely to worsen, resulting in permanent paralysis. [20]