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However in two phase 3, double-blind, randomized, controlled trials involving adults with moderate-to-severe obstructive sleep apnea and obesity, tirzepatide for 52 weeks substantially reduced apneic-hypopnic events, body weight, hypoxic burden, hsCRP concentration, and systolic blood pressure, and it improved sleep-related patient-reported ...
The first problems to occur in obese children are usually emotional or psychological. [10] Obese children often experience bullying by their peers. [11] [12] Some are harassed or discriminated against by their own family. [12] Stereotypes abound and may lead to low self-esteem and depression. [13]
Obese people tend to have raised levels of the hormone leptin, which is secreted by adipose tissue and under normal circumstances increases ventilation. In OHS, this effect is reduced. [5] [10] Furthermore, episodes of nighttime acidosis (e.g. due to sleep apnea) lead to compensation by the kidneys with retention of the alkali bicarbonate. This ...
Specialty: Otorhinolaryngology, sleep medicine: Symptoms: Pauses breathing or periods of shallow breathing during sleep, snoring, tired during the day [1] [2]: Complications: Heart attack, Cardiac arrest, stroke, diabetes, heart failure, irregular heartbeat, obesity, motor vehicle collisions, [1] Alzheimer's disease, [3] and premature death [4]
Obese subjects are vulnerable for sleep-related breathing disorders, such as sleep apnea. [2] The mechanisms of body weight having an influence on sleep-related breathing disorders are various and include possible alterations in upper airway structure, alterations in upper airway function, alterations in the balance between ventilatory drive ...
Zepbound, a drug approved by the FDA, has been shown to reduce the severity of obstructive sleep apnea in obese adults, although it is not a cure and requires weight loss to be maintained over time.
Sleep apnea is measured by the apnea-hypopnea index (AHI). An AHI is determined with a sleep study. AHI values for adults are categorized as: [2] [3] Normal: AHI<5; Mild sleep apnea: 5≤AHI<15; Moderate sleep apnea: 15≤AHI<30; Severe sleep apnea: AHI≥30; An episode is when a person hesitates to breathe or stops their breathing altogether.
Throat weakness, causing the throat to close during sleep. [4] Mispositioned jaw, often caused by tension in the muscles. [2] Obesity that has caused fat to gather in and around the throat. [3] [4] Obstruction in the nasal passageway. [2] Obstructive sleep apnea. [2] Sleep deprivation. [2] Relaxants such as alcohol or other drugs relaxing ...