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Wernicke-Korsakoff syndrome (WKS) is the combined presence of Wernicke encephalopathy (WE) and alcoholic Korsakoff syndrome (AKS [clarification needed]). Due to the close relationship between these two disorders, people with either are usually diagnosed with WKS as a single syndrome. It mainly causes vision changes, ataxia and impaired memory. [2]
Korsakoff syndrome (KS) [1] is a disorder of the central nervous system characterized by amnesia, deficits in explicit memory, and confabulation. This neurological disorder is caused by a deficiency of thiamine (vitamin B 1 ) in the brain, and it is typically associated with and exacerbated by the prolonged, excessive ingestion of alcohol . [ 2 ]
Up to 80% of WE patients who misuse alcohol develop Korsakoff's syndrome. [39] In Korsakoff's, atrophy of the thalamus and the mammillary bodies and frontal lobe involvement is usually observed. [39] In a study, half of Wernicke–Korsakoff cases had good recovery from the amnesic state, which may take from 2 months to 10 years. [2]
Sergei Sergeyevich Korsakov (Russian: Серге́й Серге́евич Ко́рсаков; 22 January 1854, Gus-Khrustalny – 1 May 1900, Moscow) was a neuropsychiatrist from the Russian Empire, known for his studies on alcoholic psychosis. His name is lent to the eponymous Korsakov's syndrome and Wernicke–Korsakoff syndrome.
Wernicke encephalopathy: an acute neurological syndrome of ophthalmoparesis, ataxia, and encephalopathy brought on by thiamine deficiency. Wernicke–Korsakoff syndrome , also called Korsakoff psychosis : a subacute dementia syndrome, often following Wernicke encephalopathy, characterized clinically by confabulation and clinicopathologically ...
Korsakoff's syndrome and Wernicke–Korsakoff syndrome are particular forms of alcohol related brain injury which may be related to alcohol related dementia. [18] Many experts use the terms alcohol (or alcoholic) dementia to describe a specific form of ARD, characterized by impaired executive function (planning, thinking, and judgment). [5]
Alcohol can cause Wernicke encephalopathy and Korsakoff syndrome which frequently occur simultaneously, known as Wernicke–Korsakoff syndrome. [161] Lesions, or brain abnormalities, are typically located in the diencephalon which result in anterograde and retrograde amnesia, or memory loss. [161]
Wernicke-Korsakoff Syndrome: A well described syndrome of neurological and cognitive problems that comprises both Wernicke's Encephalopathy (WE) and Korsakoff Syndrome (KS). It is often characterized by impairment in memory formation and is caused by long term thiamine deficiency. [18]
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