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  2. Spindle apparatus - Wikipedia

    en.wikipedia.org/wiki/Spindle_apparatus

    The completion of spindle formation is a crucial transition point in the cell cycle called the spindle assembly checkpoint. If chromosomes are not properly attached to the mitotic spindle by the time of this checkpoint, the onset of anaphase will be delayed. [36]

  3. Spindle checkpoint - Wikipedia

    en.wikipedia.org/wiki/Spindle_checkpoint

    The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic checkpoint, is a cell cycle checkpoint during metaphase of mitosis or meiosis that prevents the separation of the duplicated chromosomes until each chromosome is properly attached to the ...

  4. Mitosis - Wikipedia

    en.wikipedia.org/wiki/Mitosis

    During prophase, which occurs after G 2 interphase, the cell prepares to divide by tightly condensing its chromosomes and initiating mitotic spindle formation. During interphase, the genetic material in the nucleus consists of loosely packed chromatin .

  5. Cell cycle checkpoint - Wikipedia

    en.wikipedia.org/wiki/Cell_cycle_checkpoint

    The mitotic spindle checkpoint occurs at the point in metaphase where all the chromosomes should/have aligned at the mitotic plate and be under bipolar tension. The tension created by this bipolar attachment is what is sensed, which initiates the anaphase entry.

  6. Multipolar spindles - Wikipedia

    en.wikipedia.org/wiki/Multipolar_spindles

    Multipolar spindles are spindle formations characteristic of cancer cells. Spindle formation is mostly conducted by the aster of the centrosome which it forms around itself. In a mitotic cell wherever two asters convene the formation of a spindle occurs.

  7. Aster (cell biology) - Wikipedia

    en.wikipedia.org/wiki/Aster_(cell_biology)

    The function of astral microtubules can be generally considered as determination of cell geometry. They are absolutely required for correct positioning and orientation of the mitotic spindle apparatus, and are thus involved in determining the cell division site based on the geometry and polarity of the cells.

  8. Cytokinesis - Wikipedia

    en.wikipedia.org/wiki/Cytokinesis

    The process of mitotic spindle reorganization and central spindle formation is caused by the decline of CDK1 activity during anaphase. [5] The decline of CDK1 activity at the metaphase-anaphase transition leads to dephosphorylating of inhibitory sites on multiple central spindle components.

  9. Kinetochore - Wikipedia

    en.wikipedia.org/wiki/Kinetochore

    The spindle checkpoint, or SAC (for spindle assembly checkpoint), also known as the mitotic checkpoint, is a cellular mechanism responsible for detection of: correct assembly of the mitotic spindle; attachment of all chromosomes to the mitotic spindle in a bipolar manner; congression of all chromosomes at the metaphase plate.