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Nikolsky's sign is a clinical dermatological sign, named after Pyotr Nikolsky (1858–1940), a Russian physician who trained and worked in the Russian Empire. The sign is present when slight rubbing of the skin results in exfoliation of the outermost layer.
SSSS is a clinical diagnosis. This is sometimes confirmed by isolation of S. aureus from blood, mucous membranes, or skin biopsy; however, these are often negative. Skin biopsy may show separation of the superficial layer of the epidermis (intraepidermal separation), differentiating SSSS from TEN, wherein the separation occurs at the dermo-epidermal junction (subepidermal separation).
Nikolsky's sign (gentle lateral pressure) on unaffected mucosa or skin raises a bulla. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion.
[2] [3] It is seen along with Nikolsky's sign, both used to assess the severity of some blistering diseases such as pemphigus vulgaris and severe bullous drug reactions. [ 4 ] This sign is named for the Danish physician Gustav Asboe-Hansen (1917–1989), who first described it in 1960.
Nikolsky (surname), including a list of people with the name; Nikolski Air Station, an airport located in Nikolski, Alaska; Nikolskoye Airport, an airport in Kamchatka Krai, Russia; Nikolski, a novel by Canadian writer Nicolas Dickner; Nikolsky Old Believer Monastery, a monastery near Preobrazhenskoye Cemetery in Moscow, Russia
Each zodiac sign takes up 30 degrees of the zodiac wheel, with the first decan is situated within the first 0-10 degrees, the second stretches over 11-20 degrees and the third encompasses 21-30 ...
Pyotr Vasilyevich Nikolsky (Russian: Пётр Васи́льевич Нико́льский; September 13 [O.S. September 1] 1858 – March 13, 1940) was an Imperial Russian and later Soviet dermatologist.
Executive producer Daley Pearson and "Bluey" voice actors Melanie Zanetti and Dave McCormack explain how "The Sign," the highly anticipated 28-minute special, was made.