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A scanner used to measure bone density using dual energy X-ray absorptiometry. Bone density, or bone mineral density, is the amount of bone mineral in bone tissue.The concept is of mass of mineral per volume of bone (relating to density in the physics sense), although clinically it is measured by proxy according to optical density per square centimetre of bone surface upon imaging. [1]
A normal T score is -1.0 and above, low bone density is between -1.0 and -2.5, and osteoporosis is -2.5 and lower. A Z score is just a comparison of what a patient's bone mineral density is in comparison to the average bone mineral density of a male or female of their age and weight.
At the hip, a DXA-equivalent T-score may be calculated for comparison to the WHO classification at the proximal femur as normal, osteopenia (T-Score < -1.0 and > -2.5) or osteoporosis (T-Score < -2.5). [17] This T-Score may also be used for fracture risk probability calculation in the WHO FRAX tool [18] with "T-Score" as the appropriate DXA ...
Comparison of the various grading methods in a normal distribution, including: standard deviations, cumulative percentages, percentile equivalents, z-scores, T-scores. In statistics, the standard score is the number of standard deviations by which the value of a raw score (i.e., an observed value or data point) is above or below the mean value of what is being observed or measured.
DXA scans assume a constant relationship between the amounts of lean soft tissue and adipose tissue. This assumption leads to measurement errors, with an impact on accuracy as well as precision. To reduce soft-tissue errors in DXA, DXL technology was developed in the late 1990s by a team of Swedish researchers led by Prof. Ragnar Kullenberg.
A wide variety of body composition measurement methods exist. The gold standard measurement technique for the 4-compartment model consists of a weight measurement, body density measurement using hydrostatic weighing or air displacement plethysmography, total body water calculation using isotope dilution analysis, and mineral content measurement by dual-energy X-ray absorptiometry (DEXA). [1]
Bone density between 1 and 2.5 standard deviations below the reference, or a T-score between −1.0 and −2.5, indicates osteopenia (a T-score smaller than or equal to −2.5 indicates osteoporosis). Calculation of the T-score itself may not be standardized. The ISCD recommends using Caucasian women between 20 and 29 years old as the baseline ...
Diagram showing the cumulative distribution function for the normal distribution with mean (μ) 0 and variance (σ 2) 1. These numerical values "68%, 95%, 99.7%" come from the cumulative distribution function of the normal distribution. The prediction interval for any standard score z corresponds numerically to (1 − (1 − Φ μ,σ 2 (z)) · 2).