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[22] [23] The drug is also commonly described as possessing weak anticholinergic activity by acting as an antagonist of the muscarinic acetylcholine receptors. The dextrorotatory stereoisomer , dexchlorpheniramine , has been reported to possess K d values of 15 nM for the H 1 receptor and 1,300 nM for the muscarinic acetylcholine receptors in ...
Anticholinergics (anticholinergic agents) are substances that block the action of the acetylcholine (ACh) neurotransmitter at synapses in the central and peripheral nervous system. [ 1 ] [ 2 ] These agents inhibit the parasympathetic nervous system by selectively blocking the binding of ACh to its receptor in nerve cells .
Since it is difficult to measure extrapyramidal symptoms, rating scales are commonly used to assess the severity of movement disorders. The Simpson-Angus Scale (SAS), Barnes Akathisia Rating Scale (BARS), Abnormal Involuntary Movement Scale (AIMS), and Extrapyramidal Symptom Rating Scale (ESRS) are rating scales frequently used for such assessment and are not weighted for diagnostic purposes ...
Anticholinergic – side-effects impacting the choline system. Allergic reaction. Prolactin – many neuroleptics affect hormones particularly prolactin. As well as, Red herrings – designed to trap people who over-rate symptoms.
The Shulgin Rating Scale (or "quantitative potency scale") is a simple scale for reporting the subjective effect of psychoactive substances at a given dosage, ...
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Under Acute Anticholinergic Syndrome/Remedies the article states " Previously, reversible cholinergic agents such as physostigmine were used but this was found to increase the risk of cardiac toxicity (no reference; unable to verify in PubMed literature search 12/31/11) [citation needed]" A Google Scholar search produces a link to THA—A ...
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