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Vitamin B 12 deficiency can be determined, but not always. [15] This means it measures forms of vitamin B 12 that are "active" and can be used by the body, as well as the "inactive" forms, which cannot. [152] Vitamin B 12 deficiency can be found within normal levels, so clinical symptoms should be taken into account when a diagnosis is made. [2]
A B12 deficiency can cause symptoms like fatigue and constipation and could even lead to permanent neurological damage if left untreated. Here is how to recognize a B12 deficiency, its potential ...
Pernicious anemia is a disease where not enough red blood cells are produced due to a deficiency of vitamin B 12. [5] Those affected often have a gradual onset. [5] The most common initial symptoms are feeling tired and weak. [4]
Vitamin B 12 deficiency has been observed in between 40% and 80% of the vegetarian population who do not also take a vitamin B 12 supplement or consume vitamin-fortified food. [36] In Hong Kong and India, vitamin B 12 deficiency has been found in roughly 80% of the vegan population.
Symptoms “A B12 deficiency can cause physical and neurological symptoms, and research is also growing to support that it can also cause psychological issues as well,” says Shapiro.
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Pernicious anaemia is a lifelong condition that affects nearly 5 in 100,000 people in the UK.
Vitamin B 12 deficiency is but one among the conditions that can lead to dysfunction of this enzyme and a buildup of its substrate, methylmalonic acid, the elevated level of which can be detected in the urine and blood. Due to the lack of available radioactive Vitamin B 12, the Schilling test is now largely a historical artifact.
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