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Nucleoside analog reverse-transcriptase inhibitors (NARTIs or NRTIs) compose the first class of antiretroviral drugs developed. In order to be incorporated into the viral DNA, NRTIs must be activated in the cell by the addition of three phosphate groups to their deoxyribose moiety, to form NRTI triphosphates.
Nucleoside analog reverse transcriptase inhibitors (21 P) Pages in category "Reverse transcriptase inhibitors" The following 8 pages are in this category, out of 8 total.
Integrase inhibitor Remdesivir: COVID-19: viral RNA polymerase inhibitor Ribavirin: Hepatitis C [15] nucleoside analogue reverse transcriptase inhibitor: Rilpivirine (Edurant) [16] HIV Rimantadine: Influenza A: M2 proton channel antagonist Ritonavir: HIV HIV-1 protease inhibitor Saquinavir: HIV Simeprevir (Olysio) Hepatitis C Sofosbuvir ...
Nucleoside reverse-transcriptase inhibitors (NRTI) and nucleotide reverse-transcriptase inhibitors (NtRTI) are nucleoside and nucleotide analogues which inhibit reverse transcription. HIV is an RNA virus, so it can not be integrated into the DNA in the nucleus of the human cell unless it is first "reverse" transcribed into DNA.
There is a large family of nucleoside analogue reverse transcriptase inhibitors, because DNA production by reverse transcriptase is very different from normal human DNA replication, so it is possible to design nucleoside analogues that are preferentially incorporated by the former. Some nucleoside analogues, however, can function both as NRTIs ...
[3] [4] Antiretroviral drugs for the treatment of HIV infections belong to six categories: Nucleoside and nucleotide reverse-transcriptase inhibitors, Non-nucleoside reverse-transcriptase inhibitors, protease inhibitors, entry inhibitors, co-receptor inhibitors and integrase inhibitors. [4] The reverse transcriptase of HIV-1 has been the main ...
Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) of HIV-1. Tenofovir is a nucleotide reverse transcriptase inhibitor of HIV-1, and it can be classified as an NtRTI. These three drugs work in combination to target the HIV reverse transcriptase protein in three ways, which reduces the virus's capacity to mutate. [5]
Pages in category "Nucleoside analog reverse transcriptase inhibitors" The following 21 pages are in this category, out of 21 total. This list may not reflect recent changes .